SOAT1 methylation is associated with coronary heart disease
Abstract Background This study was designed to investigate whether differential DNA methylationin of cholesterol absorption candidate genes can function as a biomarker for patients with coronary heart disease (CHD). Methods DNA methylation levels of the candidate genes FLOT1, FLOT2 and SOAT1 were me...
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doaj-3f70483d31074273b3e265f3a1ab4ec82020-11-25T04:07:19ZengBMCLipids in Health and Disease1476-511X2019-11-011811610.1186/s12944-019-1138-9SOAT1 methylation is associated with coronary heart diseaseJialin Abuzhalihan0Yong-Tao Wang1Yi-Tong Ma2Zhen-Yan Fu3Yi-Ning Yang4Xiang Ma5Xiao-Mei Li6Fen Liu7Bang-Dang Chen8Department of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical UniversityXinjiang Key Laboratory of Cardiovascular Disease ResearchXinjiang Key Laboratory of Cardiovascular Disease ResearchAbstract Background This study was designed to investigate whether differential DNA methylationin of cholesterol absorption candidate genes can function as a biomarker for patients with coronary heart disease (CHD). Methods DNA methylation levels of the candidate genes FLOT1, FLOT2 and SOAT1 were measured in peripheral blood leukocytes (PBLs) from 99 patients diagnosed with CHD and 89 control subjects without CHD. A total of 110 CPG sites around promoter regions of them were examined. Results Compared with groups without CHD, patients with CHD had lower methylation levels of SOAT1 (P<0.001). When each candidate genes were divided into different target segments, patients with CHD also had lower methylation levels of SOAT1 than patients without (P = 0.005). After adjustment of other confounders, methylation levels of SOAT1 were still associated with CHD (P = 0.001, OR = 0.290, 95% CI: 0.150–0.561). Conclusions SOAT1 methylation may be associated with development of CHD. Patients with lower methylation levels in SOAT1 may have increased risks for CHD. Further studies on the specific mechanisms of this relationship are necessary.http://link.springer.com/article/10.1186/s12944-019-1138-9DNA methylationCoronary heart diseaseSOAT1Cholesterol absorption |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jialin Abuzhalihan Yong-Tao Wang Yi-Tong Ma Zhen-Yan Fu Yi-Ning Yang Xiang Ma Xiao-Mei Li Fen Liu Bang-Dang Chen |
spellingShingle |
Jialin Abuzhalihan Yong-Tao Wang Yi-Tong Ma Zhen-Yan Fu Yi-Ning Yang Xiang Ma Xiao-Mei Li Fen Liu Bang-Dang Chen SOAT1 methylation is associated with coronary heart disease Lipids in Health and Disease DNA methylation Coronary heart disease SOAT1 Cholesterol absorption |
author_facet |
Jialin Abuzhalihan Yong-Tao Wang Yi-Tong Ma Zhen-Yan Fu Yi-Ning Yang Xiang Ma Xiao-Mei Li Fen Liu Bang-Dang Chen |
author_sort |
Jialin Abuzhalihan |
title |
SOAT1 methylation is associated with coronary heart disease |
title_short |
SOAT1 methylation is associated with coronary heart disease |
title_full |
SOAT1 methylation is associated with coronary heart disease |
title_fullStr |
SOAT1 methylation is associated with coronary heart disease |
title_full_unstemmed |
SOAT1 methylation is associated with coronary heart disease |
title_sort |
soat1 methylation is associated with coronary heart disease |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2019-11-01 |
description |
Abstract Background This study was designed to investigate whether differential DNA methylationin of cholesterol absorption candidate genes can function as a biomarker for patients with coronary heart disease (CHD). Methods DNA methylation levels of the candidate genes FLOT1, FLOT2 and SOAT1 were measured in peripheral blood leukocytes (PBLs) from 99 patients diagnosed with CHD and 89 control subjects without CHD. A total of 110 CPG sites around promoter regions of them were examined. Results Compared with groups without CHD, patients with CHD had lower methylation levels of SOAT1 (P<0.001). When each candidate genes were divided into different target segments, patients with CHD also had lower methylation levels of SOAT1 than patients without (P = 0.005). After adjustment of other confounders, methylation levels of SOAT1 were still associated with CHD (P = 0.001, OR = 0.290, 95% CI: 0.150–0.561). Conclusions SOAT1 methylation may be associated with development of CHD. Patients with lower methylation levels in SOAT1 may have increased risks for CHD. Further studies on the specific mechanisms of this relationship are necessary. |
topic |
DNA methylation Coronary heart disease SOAT1 Cholesterol absorption |
url |
http://link.springer.com/article/10.1186/s12944-019-1138-9 |
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