Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma
Abstract Background To estimate the prognostic value of inflammatory markers in patients with laryngeal squamous cell carcinoma (LSCC). Methods A total of 361 resected LSCC patients were included. The preoperative and postoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (...
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doaj-3f7274fdbb6d4eaa884993489a6393372020-11-25T00:55:54ZengBMCBMC Cancer1471-24072018-08-011811910.1186/s12885-018-4730-xSurvival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinomaLinyan Chen0Hao Zeng1Jiapeng Yang2Yuqing Lu3Dan Zhang4Jinggan Wang5Chienyun Kuang6Sha Zhu7Manni Wang8Xuelei Ma9Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation CenterDepartment of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation CenterDepartment of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation CenterThe People’s Hospital of HechiDepartment of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation CenterDepartment of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation CenterWest China School of Stomatology, Sichuan UniversityDepartment of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation CenterDepartment of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation CenterDepartment of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation CenterAbstract Background To estimate the prognostic value of inflammatory markers in patients with laryngeal squamous cell carcinoma (LSCC). Methods A total of 361 resected LSCC patients were included. The preoperative and postoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), alkaline phosphatase (ALP) and l actate dehydrogenase (LDH) were assessed. The Kaplan-Meier survival analysis and Cox regression analysis were conducted on overall survival (OS) and progression-free survival (PFS). Results Both Kaplan-Meier analysis and univariate analysis demonstrated significant prognostic value of preoperative and postoperative NLR, PLR and MLR. However, only preoperative ALP was predictive of OS and PFS, and LDH failed to be predictor of OS and PFS. The multivariate analysis showed that preoperative NLR (OS: HR = 1.64, 95%CI: 1.06–2.54, p = 0.026; PFS: HR = 1.52, 95%CI: 1.04–2.23, p = 0.029) and postoperative MLR (OS: HR = 2.02, 95%CI: 1.29–3.14, p = 0.002; PFS: HR = 1.57, 95%CI: 1.05–2.34, p = 0.026) were independently related with survival. Conclusions The elevated preoperative NLR, PLR, MLR and ALP were significantly associated with worse survival and cancer progression. The preoperative NLR and postoperative MLR might be independent prognostic markers of OS and PFS in LSCC patients undergoing surgical resection.http://link.springer.com/article/10.1186/s12885-018-4730-xLaryngeal cancerNeutrophilLymphocytePlateletMonocytePrognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Linyan Chen Hao Zeng Jiapeng Yang Yuqing Lu Dan Zhang Jinggan Wang Chienyun Kuang Sha Zhu Manni Wang Xuelei Ma |
spellingShingle |
Linyan Chen Hao Zeng Jiapeng Yang Yuqing Lu Dan Zhang Jinggan Wang Chienyun Kuang Sha Zhu Manni Wang Xuelei Ma Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma BMC Cancer Laryngeal cancer Neutrophil Lymphocyte Platelet Monocyte Prognosis |
author_facet |
Linyan Chen Hao Zeng Jiapeng Yang Yuqing Lu Dan Zhang Jinggan Wang Chienyun Kuang Sha Zhu Manni Wang Xuelei Ma |
author_sort |
Linyan Chen |
title |
Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma |
title_short |
Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma |
title_full |
Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma |
title_fullStr |
Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma |
title_full_unstemmed |
Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma |
title_sort |
survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2018-08-01 |
description |
Abstract Background To estimate the prognostic value of inflammatory markers in patients with laryngeal squamous cell carcinoma (LSCC). Methods A total of 361 resected LSCC patients were included. The preoperative and postoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), alkaline phosphatase (ALP) and l actate dehydrogenase (LDH) were assessed. The Kaplan-Meier survival analysis and Cox regression analysis were conducted on overall survival (OS) and progression-free survival (PFS). Results Both Kaplan-Meier analysis and univariate analysis demonstrated significant prognostic value of preoperative and postoperative NLR, PLR and MLR. However, only preoperative ALP was predictive of OS and PFS, and LDH failed to be predictor of OS and PFS. The multivariate analysis showed that preoperative NLR (OS: HR = 1.64, 95%CI: 1.06–2.54, p = 0.026; PFS: HR = 1.52, 95%CI: 1.04–2.23, p = 0.029) and postoperative MLR (OS: HR = 2.02, 95%CI: 1.29–3.14, p = 0.002; PFS: HR = 1.57, 95%CI: 1.05–2.34, p = 0.026) were independently related with survival. Conclusions The elevated preoperative NLR, PLR, MLR and ALP were significantly associated with worse survival and cancer progression. The preoperative NLR and postoperative MLR might be independent prognostic markers of OS and PFS in LSCC patients undergoing surgical resection. |
topic |
Laryngeal cancer Neutrophil Lymphocyte Platelet Monocyte Prognosis |
url |
http://link.springer.com/article/10.1186/s12885-018-4730-x |
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