Stress during first pregnancy increases seizure threshold in adult male offspring

• Main Authors: Peyman Pajand, Mahmoud Elahdadi Salmani, Hooman Shajiee, Hasan Abiri, Iran Goudarzi, Kataneh Abrari
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2014-01-01
• Series: Iranian Journal of Basic Medical Sciences
• Subjects: Kindling Pentylenetetrazol Seizure Pregnancy stress
• Online Access: http://ijbms.mums.ac.ir/pdf_2153_99b650bbf1d71ac9441097d195901c1c.html

  Objective(s): Stress induces many homeostatic aberrations which are followed by lifelong allostatic responses. Epilepsy is developed or influenced by different environmental factors, i.e. prenatal stress which makes many contradictory developmental changes in seizure threshold and intensity. We investigated the potential seizure response of the rat offspring to prenatal stress; the stress which was applied to their mothers.   Materials and Methods:   Nine day heterogeneous sequential stress (HSS) model was used before and during the first and before the second pregnancy. The kindling was induced using 13 IP injections of pentylenetetrazol (PTZ) every 48 hr to adult male Wistar rat's offspring.   Results: The results of the present study demonstrated that, before pregnancy stress decreased the rate of kindling (P