PARP1-Driven Apoptosis in Chronic Lymphocytic Leukemia

PARP1-Driven Apoptosis in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is considered a malignancy resulting from defects in apoptosis. For this reason, targeting apoptotic pathways in CLL may be valuable for its management. Poly [ADP-ribose] polymerase 1 (PARP1) is the main member of a family of nuclear enzymes that act as DNA damage...

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Bibliographic Details
Main Authors: Panagiotis T. Diamantopoulos, Maria Sofotasiou, Vasiliki Papadopoulou, Katerina Polonyfi, Theodoros Iliakis, Nora-Athina Viniou
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/106713

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