HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection.
In the research data on the study of interconnection between polymorphism of HLA DRB1 genes and the risk of HIV infection and co-infection and HIV/tuberculosis are presented.The cohort of observation was HIV-infected individuals with different clinical stages aged from 24 to 58 years, average age be...
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SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"
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doaj-3f97715b338f495b8b820441431689c72020-11-25T01:49:19ZengSE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"Medičnì Perspektivi2307-04042017-10-01223818810.26641/2307-0404.2017.3.111930111930HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection.L. R. Shostakovych-KoretskayaO. O. VolikovaK. Y. LytvynI. O. GubarO. A. KushnerovaO. V. ShevelevaIn the research data on the study of interconnection between polymorphism of HLA DRB1 genes and the risk of HIV infection and co-infection and HIV/tuberculosis are presented.The cohort of observation was HIV-infected individuals with different clinical stages aged from 24 to 58 years, average age being 38 years. 90 patients (89.2%) received HAART.There were 32 (31.4%) HIV-infected patients with manifestations of tuberculosis, 70 (68.6%) HIV patients without manifestations of tuberculosis. Among the cohort of HIV-infected patients with manifestations of tuberculosis, pulmonary forms of tuberculosis was in 32 (100%), of which extrapulmonary forms of tuberculosis were in 12 (37.5%) patients. The majority of cases of tuberculosis occurred in HIV-infected patients in the IV clinical stage. Among HIV-infected patients, the following alleles of the HLA gene DRB1 *01 (10%) *04 (10%) *07 (13%), *11 (15%), *13 (13%), *15 (10%) occurred more often, HLA DRB1 *03 *08 *09 *10, *12, *14, *16, * 17, *18 were rarely found (1-7%). Similar distributions of DRB1 genes were noted among residents of the region with the dominance of HLA DRB1 *01 *04 *07 *11 *13 and *15. With the presence of alleles of the locus DRB1 *13, DRB1 *03 and DRB1 *08, the greatest probability of co-infection of tuberculosis was observed in HIV-infected patients. The risk of tuberculosis is by 2 times higher with a significant difference in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 4.4 times and DRB1 *08 – by 5.4 times. Significant chances of tuberculosis occurrence are higher – by 2.6 times in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 5.1 times and DRB1 *08 – by 6.4 times. Thus, the variability of the HLA DRB1 locus alleles may play a predisposing or protective role in the occurrence of tuberculosis in HIV-infected patients.http://journals.uran.ua/index.php/2307-0404/article/view/111930HLA DRB1 gene polymorphismHIV-infected patientsco-infection HIV/tuberculosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
L. R. Shostakovych-Koretskaya O. O. Volikova K. Y. Lytvyn I. O. Gubar O. A. Kushnerova O. V. Sheveleva |
spellingShingle |
L. R. Shostakovych-Koretskaya O. O. Volikova K. Y. Lytvyn I. O. Gubar O. A. Kushnerova O. V. Sheveleva HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection. Medičnì Perspektivi HLA DRB1 gene polymorphism HIV-infected patients co-infection HIV/tuberculosis |
author_facet |
L. R. Shostakovych-Koretskaya O. O. Volikova K. Y. Lytvyn I. O. Gubar O. A. Kushnerova O. V. Sheveleva |
author_sort |
L. R. Shostakovych-Koretskaya |
title |
HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection. |
title_short |
HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection. |
title_full |
HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection. |
title_fullStr |
HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection. |
title_full_unstemmed |
HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection. |
title_sort |
hla drb1 polymorphism and risk of hiv/tuberculosis co-infection. |
publisher |
SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" |
series |
Medičnì Perspektivi |
issn |
2307-0404 |
publishDate |
2017-10-01 |
description |
In the research data on the study of interconnection between polymorphism of HLA DRB1 genes and the risk of HIV infection and co-infection and HIV/tuberculosis are presented.The cohort of observation was HIV-infected individuals with different clinical stages aged from 24 to 58 years, average age being 38 years. 90 patients (89.2%) received HAART.There were 32 (31.4%) HIV-infected patients with manifestations of tuberculosis, 70 (68.6%) HIV patients without manifestations of tuberculosis. Among the cohort of HIV-infected patients with manifestations of tuberculosis, pulmonary forms of tuberculosis was in 32 (100%), of which extrapulmonary forms of tuberculosis were in 12 (37.5%) patients. The majority of cases of tuberculosis occurred in HIV-infected patients in the IV clinical stage. Among HIV-infected patients, the following alleles of the HLA gene DRB1 *01 (10%) *04 (10%) *07 (13%), *11 (15%), *13 (13%), *15 (10%) occurred more often, HLA DRB1 *03 *08 *09 *10, *12, *14, *16, * 17, *18 were rarely found (1-7%). Similar distributions of DRB1 genes were noted among residents of the region with the dominance of HLA DRB1 *01 *04 *07 *11 *13 and *15. With the presence of alleles of the locus DRB1 *13, DRB1 *03 and DRB1 *08, the greatest probability of co-infection of tuberculosis was observed in HIV-infected patients. The risk of tuberculosis is by 2 times higher with a significant difference in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 4.4 times and DRB1 *08 – by 5.4 times. Significant chances of tuberculosis occurrence are higher – by 2.6 times in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 – by 5.1 times and DRB1 *08 – by 6.4 times. Thus, the variability of the HLA DRB1 locus alleles may play a predisposing or protective role in the occurrence of tuberculosis in HIV-infected patients. |
topic |
HLA DRB1 gene polymorphism HIV-infected patients co-infection HIV/tuberculosis |
url |
http://journals.uran.ua/index.php/2307-0404/article/view/111930 |
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