The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response.

The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response.

Adenoviral vectors (AdV) activate multiple signaling pathways associated with innate immune responses, including mitogen-activated protein kinases (MAPKs). In this study, we investigated how systemically-injected AdVs activate two MAPK pathways (p38 and ERK) and the contribution of these kinases to...

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Bibliographic Details
Main Authors: Jeffrey S Smith, Zhili Xu, Jie Tian, Donna J Palmer, Philip Ng, Andrew P Byrnes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3203151?pdf=render

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