Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania

Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania

<p>Abstract</p> <p>Artemether-lumefantrine is currently first-line therapy of <it>Plasmodium falciparum</it> malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genot...

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Main Authors: Färnert Anna, Ursing Johan, Tolfvenstam Thomas, Rono Josea, Karlsson Lillemor, Sparrelid Elda, Lindegårdh Niklas
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Malaria Journal
Subjects:
Malaria
<it>P. falciparum</it>
Artemisinin
Lumefantrine
Sensitivity
non-immune
Online Access:http://www.malariajournal.com/content/11/1/176
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spelling doaj-3fcbd10899174e25b47be5a6f0c2f68a2020-11-25T00:26:35ZengBMCMalaria Journal1475-28752012-05-0111117610.1186/1475-2875-11-176Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from TanzaniaFärnert AnnaUrsing JohanTolfvenstam ThomasRono JoseaKarlsson LillemorSparrelid EldaLindegårdh Niklas<p>Abstract</p> <p>Artemether-lumefantrine is currently first-line therapy of <it>Plasmodium falciparum</it> malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment.</p> http://www.malariajournal.com/content/11/1/176Malaria<it>P. falciparum</it>ArtemisininLumefantrineSensitivitynon-immune
collection DOAJ
language English
format Article
sources DOAJ
author Färnert Anna
Ursing Johan
Tolfvenstam Thomas
Rono Josea
Karlsson Lillemor
Sparrelid Elda
Lindegårdh Niklas
spellingShingle Färnert Anna
Ursing Johan
Tolfvenstam Thomas
Rono Josea
Karlsson Lillemor
Sparrelid Elda
Lindegårdh Niklas
Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania
Malaria Journal
Malaria
<it>P. falciparum</it>
Artemisinin
Lumefantrine
Sensitivity
non-immune
author_facet Färnert Anna
Ursing Johan
Tolfvenstam Thomas
Rono Josea
Karlsson Lillemor
Sparrelid Elda
Lindegårdh Niklas
author_sort Färnert Anna
title Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania
title_short Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania
title_full Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania
title_fullStr Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania
title_full_unstemmed Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania
title_sort artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>plasmodium falciparum</it> malaria after returning from tanzania
publisher BMC
series Malaria Journal
issn 1475-2875
publishDate 2012-05-01
description <p>Abstract</p> <p>Artemether-lumefantrine is currently first-line therapy of <it>Plasmodium falciparum</it> malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment.</p>
topic Malaria
<it>P. falciparum</it>
Artemisinin
Lumefantrine
Sensitivity
non-immune
url http://www.malariajournal.com/content/11/1/176
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