Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q.

Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q.

Trinucleotide repeat (TNR) instability is associated with human neurodegenerative diseases and cancer. Recent studies have pointed out that DNA base excision repair (BER) mediated by DNA polymerase β (pol β) plays a crucial role in governing somatic TNR instability in a damage-location dependent man...

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Bibliographic Details
Main Authors: Yaou Ren, Yanhao Lai, Eduardo E Laverde, Ruipeng Lei, Hayley L Rein, Yuan Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5419657?pdf=render

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http://europepmc.org/articles/PMC5419657?pdf=render

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