Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design

A variety of cyclodextrin-based molecular structures, with substitutions of either primary or secondary faces of the natural oligosaccharide macrocycles of α-, β-, or γ-cyclodextrins, have been designed towards innovative applications of self-assembled cyclodextrin nanomaterials. Amphiphilic cyclo...

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Main Authors: Leïla Zerkoune, Angelina Angelova, Sylviane Lesieur
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Nanomaterials
Subjects:
Online Access:http://www.mdpi.com/2079-4991/4/3/741
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spelling doaj-3fe226136b264ab6a5db0145321c82c52020-11-24T23:15:50ZengMDPI AGNanomaterials2079-49912014-08-014374176510.3390/nano4030741nano4030741Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics DesignLeïla Zerkoune0Angelina Angelova1Sylviane Lesieur2CNRS UMR 8612 Institut Galien Paris-Sud, Paris-Sud 11 University, 92290 Châtenay-Malabry, FranceCNRS UMR 8612 Institut Galien Paris-Sud, Paris-Sud 11 University, 92290 Châtenay-Malabry, FranceCNRS UMR 8612 Institut Galien Paris-Sud, Paris-Sud 11 University, 92290 Châtenay-Malabry, FranceA variety of cyclodextrin-based molecular structures, with substitutions of either primary or secondary faces of the natural oligosaccharide macrocycles of α-, β-, or γ-cyclodextrins, have been designed towards innovative applications of self-assembled cyclodextrin nanomaterials. Amphiphilic cyclodextrins have been obtained by chemical or enzymatic modifications of their macrocycles using phospholipidyl, peptidolipidyl, cholesteryl, and oligo(ethylene oxide) anchors as well as variable numbers of grafted hydrophobic hydrocarbon or fluorinated chains. These novel compounds may self-assemble in an aqueous medium into different types of supramolecular nanoassemblies (vesicles, micelles, nanorods, nanospheres, and other kinds of nanoparticles and liquid crystalline structures). This review discusses the supramolecular nanoarchitectures, which can be formed by amphiphilic cyclodextrin derivatives in mixtures with other molecules (phospholipids, surfactants, and olygonucleotides). Biomedical applications are foreseen for nanoencapsulation of drug molecules in the hydrophobic interchain volumes and nanocavities of the amphiphilic cyclodextrins (serving as drug carriers or pharmaceutical excipients), anticancer phototherapy, gene delivery, as well as for protection of instable active ingredients through inclusion complexation in nanostructured media.http://www.mdpi.com/2079-4991/4/3/741amphiphilic cyclodextrinsself-assemblycyclodextrin nanoassembliesmixed supramolecular cyclodextrin materialsnanoparticlesnanoencapsulationgene and drug delivery
collection DOAJ
language English
format Article
sources DOAJ
author Leïla Zerkoune
Angelina Angelova
Sylviane Lesieur
spellingShingle Leïla Zerkoune
Angelina Angelova
Sylviane Lesieur
Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design
Nanomaterials
amphiphilic cyclodextrins
self-assembly
cyclodextrin nanoassemblies
mixed supramolecular cyclodextrin materials
nanoparticles
nanoencapsulation
gene and drug delivery
author_facet Leïla Zerkoune
Angelina Angelova
Sylviane Lesieur
author_sort Leïla Zerkoune
title Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design
title_short Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design
title_full Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design
title_fullStr Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design
title_full_unstemmed Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design
title_sort nano-assemblies of modified cyclodextrins and their complexes with guest molecules: incorporation in nanostructured membranes and amphiphile nanoarchitectonics design
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2014-08-01
description A variety of cyclodextrin-based molecular structures, with substitutions of either primary or secondary faces of the natural oligosaccharide macrocycles of α-, β-, or γ-cyclodextrins, have been designed towards innovative applications of self-assembled cyclodextrin nanomaterials. Amphiphilic cyclodextrins have been obtained by chemical or enzymatic modifications of their macrocycles using phospholipidyl, peptidolipidyl, cholesteryl, and oligo(ethylene oxide) anchors as well as variable numbers of grafted hydrophobic hydrocarbon or fluorinated chains. These novel compounds may self-assemble in an aqueous medium into different types of supramolecular nanoassemblies (vesicles, micelles, nanorods, nanospheres, and other kinds of nanoparticles and liquid crystalline structures). This review discusses the supramolecular nanoarchitectures, which can be formed by amphiphilic cyclodextrin derivatives in mixtures with other molecules (phospholipids, surfactants, and olygonucleotides). Biomedical applications are foreseen for nanoencapsulation of drug molecules in the hydrophobic interchain volumes and nanocavities of the amphiphilic cyclodextrins (serving as drug carriers or pharmaceutical excipients), anticancer phototherapy, gene delivery, as well as for protection of instable active ingredients through inclusion complexation in nanostructured media.
topic amphiphilic cyclodextrins
self-assembly
cyclodextrin nanoassemblies
mixed supramolecular cyclodextrin materials
nanoparticles
nanoencapsulation
gene and drug delivery
url http://www.mdpi.com/2079-4991/4/3/741
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