ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS
Objective. The purpose of the present study was to assess the relevance of therapeutic drug monitoring in spondyloarthritis patients, by determining drug serum levels and anti-drug antibodies and estimating cut-off values for three TNF inhibitors. Methods. Over one year, we enrolled 100 patients w...
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doaj-3fefa38cb0c241f4ba7f48c1587dd4902021-09-08T09:24:31ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862016-09-0125312713510.37897/RJR.2016.3.5ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTSClaudia Deaconu0Daniela Opris1Ruxandra Ionescu2Department of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, BucharestDepartment of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestDepartment of Rheumatology and Internal Medicine, Sfanta Maria Clinical Hospital, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestObjective. The purpose of the present study was to assess the relevance of therapeutic drug monitoring in spondyloarthritis patients, by determining drug serum levels and anti-drug antibodies and estimating cut-off values for three TNF inhibitors. Methods. Over one year, we enrolled 100 patients with SpA, under consequent treatment with adalimumab (ADL), etanercept (ETA) or infliximab (IFX). Demographic, clinical (BASDAI, ASDAS) and laboratory (ESR, CRP) data was collected together with drug serum level and anti-drug antibodies using the ELISA technique. The statistical analysis was performed using the SPSS software, version 20.0 with the aid of Student t-test, Spearman and Pearson tests. Results. Out of the study cohort, 35% were on ADL, 33% on IFX, and 32% under ETA treatment. Undetectable drug levels correlated to the presence of anti-drug antibodies and to disease activity scores. There were no identified anti-ETA antibodies. For this study lot trough levels are estimated between 2 and 4 μg/mL for an ASDAS-CRP under 2.1. Conclusion. Serum drug level measurement and anti-drug antibody detection can be used as a completion to a clinician’s tools in assessing disease activity, leading to an optimal and personalized manner of patient management.https://rjr.com.ro/articles/2016.3/RJR_2016_3_Art-05.pdfspondyloarthritisanti-tnf therapydrug serum levelthrough levelpersonalized medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudia Deaconu Daniela Opris Ruxandra Ionescu |
spellingShingle |
Claudia Deaconu Daniela Opris Ruxandra Ionescu ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS Romanian Journal of Rheumatology spondyloarthritis anti-tnf therapy drug serum level through level personalized medicine |
author_facet |
Claudia Deaconu Daniela Opris Ruxandra Ionescu |
author_sort |
Claudia Deaconu |
title |
ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS |
title_short |
ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS |
title_full |
ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS |
title_fullStr |
ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS |
title_full_unstemmed |
ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS |
title_sort |
assessing anti-tnf trough levels and its applicability in daily practice in spondyloarthritis patients |
publisher |
Amaltea Medical Publishing House |
series |
Romanian Journal of Rheumatology |
issn |
1843-0791 2069-6086 |
publishDate |
2016-09-01 |
description |
Objective. The purpose of the present study was to assess the relevance of therapeutic drug monitoring in spondyloarthritis patients, by determining drug serum levels and anti-drug antibodies and estimating cut-off values for three TNF inhibitors.
Methods. Over one year, we enrolled 100 patients with SpA, under consequent treatment with adalimumab (ADL), etanercept (ETA) or infliximab (IFX). Demographic, clinical (BASDAI, ASDAS) and laboratory (ESR, CRP) data was collected together with drug serum level and anti-drug antibodies using the ELISA technique. The statistical analysis was performed using the SPSS software, version 20.0 with the aid of Student t-test, Spearman and Pearson tests.
Results. Out of the study cohort, 35% were on ADL, 33% on IFX, and 32% under ETA treatment. Undetectable drug levels correlated to the presence of anti-drug antibodies and to disease activity scores. There were no identified anti-ETA antibodies. For this study lot trough levels are estimated between 2 and 4 μg/mL for an ASDAS-CRP under 2.1.
Conclusion. Serum drug level measurement and anti-drug antibody detection can be used as a completion to a clinician’s tools in assessing disease activity, leading to an optimal and personalized manner of patient management. |
topic |
spondyloarthritis anti-tnf therapy drug serum level through level personalized medicine |
url |
https://rjr.com.ro/articles/2016.3/RJR_2016_3_Art-05.pdf |
work_keys_str_mv |
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