Effect of maternal diabetes on female offspring
Objective To evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before...
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doaj-3ff86d76c6f44c68ab6996983d3f89992020-11-24T22:26:11ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-638512441341910.1590/S1679-45082014AO3200S1679-45082014000400413Effect of maternal diabetes on female offspringJuliana de Oliveira MartinsMaurício Isaac PanícioMarcos Paulo Suehiro DantasGuiomar Nascimento GomesObjective To evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the cages, blood samples were withdrawn. One month after pregnancy, new blood and urine sample were collected. Kidney function was evaluated through proteinuria, plasma urea, plasma creatinine, creatinine excretion rate, urinary flow, and creatinine clearance.Results The female offspring from diabetic mothers showed an increase in blood pressure, and a decrease in glomerular filtration rate in relation to the control group.Conclusion Hyperglycemia during pregnancy was capable of causing an increase in blood pressure and kidney dysfunction in the female offspring.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000400413&lng=en&tlng=enPrenhezDesenvolvimento fetalDiabetes mellitus experimentalHipertensãoUreiaCreatininaEstreptozocina/administração & dosagem |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juliana de Oliveira Martins Maurício Isaac Panício Marcos Paulo Suehiro Dantas Guiomar Nascimento Gomes |
spellingShingle |
Juliana de Oliveira Martins Maurício Isaac Panício Marcos Paulo Suehiro Dantas Guiomar Nascimento Gomes Effect of maternal diabetes on female offspring Einstein (São Paulo) Prenhez Desenvolvimento fetal Diabetes mellitus experimental Hipertensão Ureia Creatinina Estreptozocina/administração & dosagem |
author_facet |
Juliana de Oliveira Martins Maurício Isaac Panício Marcos Paulo Suehiro Dantas Guiomar Nascimento Gomes |
author_sort |
Juliana de Oliveira Martins |
title |
Effect of maternal diabetes on female offspring |
title_short |
Effect of maternal diabetes on female offspring |
title_full |
Effect of maternal diabetes on female offspring |
title_fullStr |
Effect of maternal diabetes on female offspring |
title_full_unstemmed |
Effect of maternal diabetes on female offspring |
title_sort |
effect of maternal diabetes on female offspring |
publisher |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
series |
Einstein (São Paulo) |
issn |
2317-6385 |
description |
Objective To evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the cages, blood samples were withdrawn. One month after pregnancy, new blood and urine sample were collected. Kidney function was evaluated through proteinuria, plasma urea, plasma creatinine, creatinine excretion rate, urinary flow, and creatinine clearance.Results The female offspring from diabetic mothers showed an increase in blood pressure, and a decrease in glomerular filtration rate in relation to the control group.Conclusion Hyperglycemia during pregnancy was capable of causing an increase in blood pressure and kidney dysfunction in the female offspring. |
topic |
Prenhez Desenvolvimento fetal Diabetes mellitus experimental Hipertensão Ureia Creatinina Estreptozocina/administração & dosagem |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000400413&lng=en&tlng=en |
work_keys_str_mv |
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