Solving up the jigsaw puzzle: Necrolytic Migratory Erythema Associated with Multifocal Neuroendocrine Tumor of Pancreas, A case report
Introduction Necrolytic migratory erythema (NME) is a disorder that is recognized by reddish, migrating areas of blistering that heal with pigmentation. It is a characteristic rash that is often recognized by its distinct appearance and history. It has strong association with glucagonoma, a pancrea...
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doaj-3ffa350e63084b2b89784e9a98c39e572021-04-03T16:27:19ZengBulgarian Association of Young SurgeonsInternational Journal of Surgery and Medicine2367-699X2367-699X2020-10-016514http://dx.doi.org/10.5455/ijsm.Neuroendocrine-Tumor-Pancreas-case-report-06-2020Solving up the jigsaw puzzle: Necrolytic Migratory Erythema Associated with Multifocal Neuroendocrine Tumor of Pancreas, A case reportAun Jamal, Zahra Jahangir, Tabish Saleem, Jibran Mohsin , Ihtisham ul Haq, Faizan Ullah, osama shakeel, Hassaan Bari, Aamir Ali Syed, Shahid Khattak, Faisal Hanif.Introduction Necrolytic migratory erythema (NME) is a disorder that is recognized by reddish, migrating areas of blistering that heal with pigmentation. It is a characteristic rash that is often recognized by its distinct appearance and history. It has strong association with glucagonoma, a pancreatic neuroendocrine tumor arising from the alpha type islet cells. In such cases NME presents as a paraneoplastic manifestation of the disease. The diagnosis of this rare tumor depends on high index of suspicion on the basis of history and examination and relevant pathological and radiological investigations. This tumor is potentially curable by surgery. Case Presentation In this article the authors describe a 36 years old female patient with NME and a multifocal pancreatic neuroendocrine tumor with clinical features of glucagonoma syndrome. After investigations she underwent total pancreatectomy and within a few days her skin lesions and clinical symptoms started improving. Conclusion Prompt diagnosis and management are of paramount importance in the management of glucagonoma. It is possible if there is high index of suspicion and the management is done appropriately.http://www.ejos.org/index.php?fulltxt=302645291&fulltxtj=136&fulltxtp=136-1591463468.pdfnecrolytic migratory erythemaglucagonomaneuroendocrine tumorblistering skin rash |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aun Jamal, Zahra Jahangir, Tabish Saleem, Jibran Mohsin , Ihtisham ul Haq, Faizan Ullah, osama shakeel, Hassaan Bari, Aamir Ali Syed, Shahid Khattak, Faisal Hanif. |
spellingShingle |
Aun Jamal, Zahra Jahangir, Tabish Saleem, Jibran Mohsin , Ihtisham ul Haq, Faizan Ullah, osama shakeel, Hassaan Bari, Aamir Ali Syed, Shahid Khattak, Faisal Hanif. Solving up the jigsaw puzzle: Necrolytic Migratory Erythema Associated with Multifocal Neuroendocrine Tumor of Pancreas, A case report International Journal of Surgery and Medicine necrolytic migratory erythema glucagonoma neuroendocrine tumor blistering skin rash |
author_facet |
Aun Jamal, Zahra Jahangir, Tabish Saleem, Jibran Mohsin , Ihtisham ul Haq, Faizan Ullah, osama shakeel, Hassaan Bari, Aamir Ali Syed, Shahid Khattak, Faisal Hanif. |
author_sort |
Aun Jamal, Zahra Jahangir, Tabish Saleem, Jibran Mohsin , Ihtisham ul Haq, Faizan Ullah, osama shakeel, Hassaan Bari, Aamir Ali Syed, Shahid Khattak, Faisal Hanif. |
title |
Solving up the jigsaw puzzle: Necrolytic Migratory Erythema Associated with Multifocal Neuroendocrine Tumor of Pancreas, A case report |
title_short |
Solving up the jigsaw puzzle: Necrolytic Migratory Erythema Associated with Multifocal Neuroendocrine Tumor of Pancreas, A case report |
title_full |
Solving up the jigsaw puzzle: Necrolytic Migratory Erythema Associated with Multifocal Neuroendocrine Tumor of Pancreas, A case report |
title_fullStr |
Solving up the jigsaw puzzle: Necrolytic Migratory Erythema Associated with Multifocal Neuroendocrine Tumor of Pancreas, A case report |
title_full_unstemmed |
Solving up the jigsaw puzzle: Necrolytic Migratory Erythema Associated with Multifocal Neuroendocrine Tumor of Pancreas, A case report |
title_sort |
solving up the jigsaw puzzle: necrolytic migratory erythema associated with multifocal neuroendocrine tumor of pancreas, a case report |
publisher |
Bulgarian Association of Young Surgeons |
series |
International Journal of Surgery and Medicine |
issn |
2367-699X 2367-699X |
publishDate |
2020-10-01 |
description |
Introduction
Necrolytic migratory erythema (NME) is a disorder that is recognized by reddish, migrating areas of blistering that heal with pigmentation. It is a characteristic rash that is often recognized by its distinct appearance and history. It has strong association with glucagonoma, a pancreatic neuroendocrine tumor arising from the alpha type islet cells. In such cases NME presents as a paraneoplastic manifestation of the disease. The diagnosis of this rare tumor depends on high index of suspicion on the basis of history and examination and relevant pathological and radiological investigations. This tumor is potentially curable by surgery.
Case Presentation
In this article the authors describe a 36 years old female patient with NME and a multifocal pancreatic neuroendocrine tumor with clinical features of glucagonoma syndrome. After investigations she underwent total pancreatectomy and within a few days her skin lesions and clinical symptoms started improving.
Conclusion
Prompt diagnosis and management are of paramount importance in the management of glucagonoma. It is possible if there is high index of suspicion and the management is done appropriately. |
topic |
necrolytic migratory erythema glucagonoma neuroendocrine tumor blistering skin rash |
url |
http://www.ejos.org/index.php?fulltxt=302645291&fulltxtj=136&fulltxtp=136-1591463468.pdf |
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