A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in Dogs
Periodontitis, a destructive periodontal inflammatory disease, negatively impacts oral-health related quality of life. It's characterized by the generation of inflammatory mediators and the excess-production of collagenolytic tissue-destructive enzymes (especially matrix metalloproteinases, MMP...
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doaj-400b3b26a19740ae813ead47b1cf31f02021-03-01T06:03:46ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152021-03-01210.3389/fdmed.2021.609795609795A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in DogsJie Deng0Lorne M. Golub1Hsi-Ming Lee2Heta-Dinesh Bhatt3Hou-Lin Hong4Francis Johnson5Joseph Scaduto6Thomas Zimmerman7Ying Gu8Department of Orthodontics, School of Stomatology, Peking University, Beijing, ChinaDepartment of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, United StatesDepartment of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, United StatesDepartment of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, United StatesDepartment of Public Health, School of Medicine, Stony Brook University, Stony Brook, NY, United StatesDepartment of Chemistry and Pharmacological Sciences, School of Medicine, Stony Brook University, Stony Brook, NY, United StatesTraverse Biosciences, Inc., Stony Brook, NY, United StatesDivision of Laboratory Animal Resources (DLAR) at Stony Brook, Stony Brook University, Stony Brook, NY, United StatesDepartment of General Dentistry, School of Dental Medicine, Stony Brook University, Stony Brook, NY, United StatesPeriodontitis, a destructive periodontal inflammatory disease, negatively impacts oral-health related quality of life. It's characterized by the generation of inflammatory mediators and the excess-production of collagenolytic tissue-destructive enzymes (especially matrix metalloproteinases, MMPs). Many biomarkers can be used to define/diagnose disease progression. However, there is still a critical lack of specific, fast, and reliable biomarkers that correlate well with early response to treatment, which can be used to predict/monitor disease. Here, we report that an early marker, MMP-9, was found to be sensitive in response to a 1-month systemic therapy of CMC2.24, a novel chemically-modified curcumin, in beagle dogs with naturally-occurring periodontitis. In brief, eight adult female dogs with generalized periodontitis were distributed into placebo and treatment groups (n = 4/group). After a 1-h full-mouth scaling and root planing at time 0, placebo or CMC2.24 (10 mg/kg) capsules were orally-administered once/day for 1-month. Clinical periodontal parameters were measured at time 0 and 1-month; in addition, peripheral blood samples from these dogs were collected and analyzed for the pro-, activated-, and total-forms of MMP-9 by gelatin zymography. Interestingly, we found that the 1-month systemic therapy of CMC2.24 did appear to significantly reduce both pro- and activated-MMP-9 in peripheral blood at this early stage compared to placebo, prior to apparent clinical improvements seen at a later stage in a previous study (3-months). Thus, MMP-9 may serve as an early/sensitive biomarker that can precede/predict future clinical changes in disease severity and response to treatment which we observed in the long-term study in this dog model of natural periodontitis.https://www.frontiersin.org/articles/10.3389/fdmed.2021.609795/fullhost-modulation therapybloodinflammationmatrix metalloproteinase 9chemically-modified curcuminperiodontitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jie Deng Lorne M. Golub Hsi-Ming Lee Heta-Dinesh Bhatt Hou-Lin Hong Francis Johnson Joseph Scaduto Thomas Zimmerman Ying Gu |
spellingShingle |
Jie Deng Lorne M. Golub Hsi-Ming Lee Heta-Dinesh Bhatt Hou-Lin Hong Francis Johnson Joseph Scaduto Thomas Zimmerman Ying Gu A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in Dogs Frontiers in Dental Medicine host-modulation therapy blood inflammation matrix metalloproteinase 9 chemically-modified curcumin periodontitis |
author_facet |
Jie Deng Lorne M. Golub Hsi-Ming Lee Heta-Dinesh Bhatt Hou-Lin Hong Francis Johnson Joseph Scaduto Thomas Zimmerman Ying Gu |
author_sort |
Jie Deng |
title |
A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in Dogs |
title_short |
A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in Dogs |
title_full |
A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in Dogs |
title_fullStr |
A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in Dogs |
title_full_unstemmed |
A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in Dogs |
title_sort |
novel chemically-modified curcumin 2.24: short-term systemic therapy for natural periodontitis in dogs |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Dental Medicine |
issn |
2673-4915 |
publishDate |
2021-03-01 |
description |
Periodontitis, a destructive periodontal inflammatory disease, negatively impacts oral-health related quality of life. It's characterized by the generation of inflammatory mediators and the excess-production of collagenolytic tissue-destructive enzymes (especially matrix metalloproteinases, MMPs). Many biomarkers can be used to define/diagnose disease progression. However, there is still a critical lack of specific, fast, and reliable biomarkers that correlate well with early response to treatment, which can be used to predict/monitor disease. Here, we report that an early marker, MMP-9, was found to be sensitive in response to a 1-month systemic therapy of CMC2.24, a novel chemically-modified curcumin, in beagle dogs with naturally-occurring periodontitis. In brief, eight adult female dogs with generalized periodontitis were distributed into placebo and treatment groups (n = 4/group). After a 1-h full-mouth scaling and root planing at time 0, placebo or CMC2.24 (10 mg/kg) capsules were orally-administered once/day for 1-month. Clinical periodontal parameters were measured at time 0 and 1-month; in addition, peripheral blood samples from these dogs were collected and analyzed for the pro-, activated-, and total-forms of MMP-9 by gelatin zymography. Interestingly, we found that the 1-month systemic therapy of CMC2.24 did appear to significantly reduce both pro- and activated-MMP-9 in peripheral blood at this early stage compared to placebo, prior to apparent clinical improvements seen at a later stage in a previous study (3-months). Thus, MMP-9 may serve as an early/sensitive biomarker that can precede/predict future clinical changes in disease severity and response to treatment which we observed in the long-term study in this dog model of natural periodontitis. |
topic |
host-modulation therapy blood inflammation matrix metalloproteinase 9 chemically-modified curcumin periodontitis |
url |
https://www.frontiersin.org/articles/10.3389/fdmed.2021.609795/full |
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