Global analysis of A-to-I RNA editing reveals association with common disease variants

Global analysis of A-to-I RNA editing reveals association with common disease variants

RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all...

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Bibliographic Details
Main Authors: Oscar Franzén, Raili Ermel, Katyayani Sukhavasi, Rajeev Jain, Anamika Jain, Christer Betsholtz, Chiara Giannarelli, Jason C. Kovacic, Arno Ruusalepp, Josefin Skogsberg, Ke Hao, Eric E. Schadt, Johan L.M. Björkegren
Format: Article
Language:English
Published: PeerJ Inc. 2018-03-01
Series:PeerJ
Subjects:
RNA editing
Gene expression
Quantitative trait loci
RNA-seq
Bioinformatics
Biostatistics
Online Access:https://peerj.com/articles/4466.pdf

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https://peerj.com/articles/4466.pdf

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