Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone
pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NET...
Main Authors: | Cristiane Naffah de Souza, Leandro C. D. Breda, Meraj A. Khan, Sandro Rogério de Almeida, Niels Olsen Saraiva Câmara, Neil Sweezey, Nades Palaniyar |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-01-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01849/full |
Similar Items
-
Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis
by: Meraj A. Khan, et al.
Published: (2018-02-01) -
Anthracyclines Suppress Both NADPH Oxidase- Dependent and -Independent NETosis in Human Neutrophils
by: Meraj A. Khan, et al.
Published: (2019-09-01) -
Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology
by: Mithunan Ravindran, et al.
Published: (2019-08-01) -
JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis
by: Meraj A. Khan, et al.
Published: (2017-06-01) -
Progression of Cystic Fibrosis Lung Disease from Childhood to Adulthood: Neutrophils, Neutrophil Extracellular Trap (NET) Formation, and NET Degradation
by: Meraj A. Khan, et al.
Published: (2019-02-01)