The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats
The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the anti-inflammation factor and the most potent vasodilator, the CGRP holds therapeutic potentials for the treatment of cardiovascular diseases which was...
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doaj-401a97ce6a814b6491d02bee6fc3a41f2021-05-13T09:30:27ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642021-01-0128186587210.1080/10717544.2021.19020211902021The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient ratsFang Wang0Yu Deng1Jieting Wang2Luying Yu3Fadian Ding4Wei Lian5Qicai Liu6Xinhua Lin7Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, School of Pharmacy, Nano Medical Technology Research Institute, Fujian Medical UniversityHigher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, School of Pharmacy, Nano Medical Technology Research Institute, Fujian Medical UniversityHigher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, School of Pharmacy, Nano Medical Technology Research Institute, Fujian Medical UniversityHigher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, School of Pharmacy, Nano Medical Technology Research Institute, Fujian Medical UniversityCenter for Reproductive Medicine, 1st Affiliated Hospital, Fujian Medical UniversityCenter for Reproductive Medicine, 1st Affiliated Hospital, Fujian Medical UniversityCenter for Reproductive Medicine, 1st Affiliated Hospital, Fujian Medical UniversityHigher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, School of Pharmacy, Nano Medical Technology Research Institute, Fujian Medical UniversityThe calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the anti-inflammation factor and the most potent vasodilator, the CGRP holds therapeutic potentials for the treatment of cardiovascular diseases which was, however, limited by its peptide nature and short half-life. With advantages in improving the stability, circulation time and protection from degradation, the nanoparticles were promising as delivery carriers for the peptide. Nevertheless, few nanoparticulate systems were developed to deliver the CGRP peptide for the modulation of vascular or inflammatory functions instead of neural regulation. In this study, the CGRP was encapsulated into the poly (lactic-co-glycolic acid) (PLGA) nanoparticle for sustained release of CGRP in vivo. The nanoparticles recovered the systemic level of CGRP and the vascular inflammatory factors in the CGRP+/− rats comparing to the administration of (Dulbecco's Phosphate Buffered Saline) DPBS or peptide only. With the decrease of vascular wall thickness and the attenuation of the T cell infiltration in the lung, the polymer based CGRP delivery system showed potentials to facilitate the therapeutic effects of the CGRP which may help for the development of CGRP-based therapy in vascular and inflammatory disorder related diseases.http://dx.doi.org/10.1080/10717544.2021.1902021cgrpsustainable releasenanoparticlesplga deliveryinflammatory and vascular disorders |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fang Wang Yu Deng Jieting Wang Luying Yu Fadian Ding Wei Lian Qicai Liu Xinhua Lin |
spellingShingle |
Fang Wang Yu Deng Jieting Wang Luying Yu Fadian Ding Wei Lian Qicai Liu Xinhua Lin The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats Drug Delivery cgrp sustainable release nanoparticles plga delivery inflammatory and vascular disorders |
author_facet |
Fang Wang Yu Deng Jieting Wang Luying Yu Fadian Ding Wei Lian Qicai Liu Xinhua Lin |
author_sort |
Fang Wang |
title |
The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats |
title_short |
The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats |
title_full |
The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats |
title_fullStr |
The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats |
title_full_unstemmed |
The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats |
title_sort |
plga nanoparticles for sustainable release of cgrp to ameliorate the inflammatory and vascular disorders in the lung of cgrp-deficient rats |
publisher |
Taylor & Francis Group |
series |
Drug Delivery |
issn |
1071-7544 1521-0464 |
publishDate |
2021-01-01 |
description |
The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the anti-inflammation factor and the most potent vasodilator, the CGRP holds therapeutic potentials for the treatment of cardiovascular diseases which was, however, limited by its peptide nature and short half-life. With advantages in improving the stability, circulation time and protection from degradation, the nanoparticles were promising as delivery carriers for the peptide. Nevertheless, few nanoparticulate systems were developed to deliver the CGRP peptide for the modulation of vascular or inflammatory functions instead of neural regulation. In this study, the CGRP was encapsulated into the poly (lactic-co-glycolic acid) (PLGA) nanoparticle for sustained release of CGRP in vivo. The nanoparticles recovered the systemic level of CGRP and the vascular inflammatory factors in the CGRP+/− rats comparing to the administration of (Dulbecco's Phosphate Buffered Saline) DPBS or peptide only. With the decrease of vascular wall thickness and the attenuation of the T cell infiltration in the lung, the polymer based CGRP delivery system showed potentials to facilitate the therapeutic effects of the CGRP which may help for the development of CGRP-based therapy in vascular and inflammatory disorder related diseases. |
topic |
cgrp sustainable release nanoparticles plga delivery inflammatory and vascular disorders |
url |
http://dx.doi.org/10.1080/10717544.2021.1902021 |
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