The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis
Introduction. Early diagnosis and treatment of neonatal sepsis may help decrease neonatal mortality. Aim of the Study. To evaluate the role of pancreatic stone protein as a marker for early onset neonatal sepsis. Methods. A hospital-based prospective study was conducted on 104 (52 uninfected and 52...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2016-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2016/1035856 |
id |
doaj-4021337c3d224973aea80219b1aa9d19 |
---|---|
record_format |
Article |
spelling |
doaj-4021337c3d224973aea80219b1aa9d192020-11-25T00:32:53ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/10358561035856The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal SepsisAnwar A. Rass0Mohamed A. Talat1Mohamed A. Arafa2Hosam F. El-Saadany3Ezzat K. Amin4Mohamed Mohamed Abdelsalam5Mona A. Mansour6Naglaa A. Khalifa7Lamiaa Mahmoud Kamel8Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig 44519, EgyptMinistry of Health, Zagazig, EgyptClinical Pathology, Faculty of Medicine, Zagazig University, Zagazig 44519, EgyptClinical Pathology, Faculty of Medicine, Zagazig University, Zagazig 44519, EgyptIntroduction. Early diagnosis and treatment of neonatal sepsis may help decrease neonatal mortality. Aim of the Study. To evaluate the role of pancreatic stone protein as a marker for early onset neonatal sepsis. Methods. A hospital-based prospective study was conducted on 104 (52 uninfected and 52 infected neonates) admitted to the Neonatal Intensive Care Unit (NICU) of Zagazig University hospitals during the period from April 2014 to April 2015. All newborns were subjected to full history taking, careful neonatal assessment, blood, C-reactive protein (CRP), and serum pancreatic stone protein. Results. Serum PSP levels were significantly higher in the infected group than in the uninfected group. At a cutoff level of PSP 12.96 ng/mL, the sensitivity was 96.2%, the specificity was 88.5%, positive predictive value was 95.8%, negative predictive value was 89.3%, and area under the curve was 0.87. A significant positive correlation between CRP and PSP was found in infected group. Conclusion. The high negative predictive value of PSP (89.3%) indicates that the serum PSP level is a good marker for diagnosis of early onset neonatal sepsis and can be used to limit hospital stay and antibiotic use in neonates treated for suspected sepsis.http://dx.doi.org/10.1155/2016/1035856 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anwar A. Rass Mohamed A. Talat Mohamed A. Arafa Hosam F. El-Saadany Ezzat K. Amin Mohamed Mohamed Abdelsalam Mona A. Mansour Naglaa A. Khalifa Lamiaa Mahmoud Kamel |
spellingShingle |
Anwar A. Rass Mohamed A. Talat Mohamed A. Arafa Hosam F. El-Saadany Ezzat K. Amin Mohamed Mohamed Abdelsalam Mona A. Mansour Naglaa A. Khalifa Lamiaa Mahmoud Kamel The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis BioMed Research International |
author_facet |
Anwar A. Rass Mohamed A. Talat Mohamed A. Arafa Hosam F. El-Saadany Ezzat K. Amin Mohamed Mohamed Abdelsalam Mona A. Mansour Naglaa A. Khalifa Lamiaa Mahmoud Kamel |
author_sort |
Anwar A. Rass |
title |
The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis |
title_short |
The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis |
title_full |
The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis |
title_fullStr |
The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis |
title_full_unstemmed |
The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis |
title_sort |
role of pancreatic stone protein in diagnosis of early onset neonatal sepsis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
Introduction. Early diagnosis and treatment of neonatal sepsis may help decrease neonatal mortality. Aim of the Study. To evaluate the role of pancreatic stone protein as a marker for early onset neonatal sepsis. Methods. A hospital-based prospective study was conducted on 104 (52 uninfected and 52 infected neonates) admitted to the Neonatal Intensive Care Unit (NICU) of Zagazig University hospitals during the period from April 2014 to April 2015. All newborns were subjected to full history taking, careful neonatal assessment, blood, C-reactive protein (CRP), and serum pancreatic stone protein. Results. Serum PSP levels were significantly higher in the infected group than in the uninfected group. At a cutoff level of PSP 12.96 ng/mL, the sensitivity was 96.2%, the specificity was 88.5%, positive predictive value was 95.8%, negative predictive value was 89.3%, and area under the curve was 0.87. A significant positive correlation between CRP and PSP was found in infected group. Conclusion. The high negative predictive value of PSP (89.3%) indicates that the serum PSP level is a good marker for diagnosis of early onset neonatal sepsis and can be used to limit hospital stay and antibiotic use in neonates treated for suspected sepsis. |
url |
http://dx.doi.org/10.1155/2016/1035856 |
work_keys_str_mv |
AT anwararass theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT mohamedatalat theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT mohamedaarafa theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT hosamfelsaadany theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT ezzatkamin theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT mohamedmohamedabdelsalam theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT monaamansour theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT naglaaakhalifa theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT lamiaamahmoudkamel theroleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT anwararass roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT mohamedatalat roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT mohamedaarafa roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT hosamfelsaadany roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT ezzatkamin roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT mohamedmohamedabdelsalam roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT monaamansour roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT naglaaakhalifa roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis AT lamiaamahmoudkamel roleofpancreaticstoneproteinindiagnosisofearlyonsetneonatalsepsis |
_version_ |
1725318540415729664 |