Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients

• Main Authors: Eiji Ishimura, Senji Okuno, Hisanori Okazaki, Kyoko Norimine, Kenjiro Yamakawa, Tomoyuki Yamakawa, Shigeichi Shoji, Yoshiki Nishizawa, Masaaki Inaba
• Format: Article
• Language: English
• Published: Karger Publishers 2014-09-01
• Series: Kidney & Blood Pressure Research
• Subjects: Bone formation markers; Bone resorption markers; Hemodialysis; Vascular calcification; Bone-specific alkaline phosphatase
• Online Access: http://www.karger.com/Article/FullText/355807
• ISSN: 1420-4096; 1423-0143

Background/Aims: Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients was conducted, and visible vascular calcification of the hand arteries was evaluated. Serum levels of 3 bone formation markers (BAP, osteocalcin, and N-terminal propeptide of type I collagen) and 2 bone resorption markers (C-terminal telopeptide of type I collagen, and cross-linked N-telopeptide of type I collagen) were measured, along with serum intact parathyroid hormone (PTH). Results: Of 167 patients, visible vascular calcification was seen in 37 patients. Among the bone formation and resorption markers, serum BAP was significantly higher in patients with vascular calcification than in those without (pConclusions: Higher serum BAP, but not other bone markers, is significantly associated with the presence of vascular calcification in male hemodialysis patients.