Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14389-8 |
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Nikos Papadimitriou Niki Dimou Konstantinos K. Tsilidis Barbara Banbury Richard M. Martin Sarah J. Lewis Nabila Kazmi Timothy M. Robinson Demetrius Albanes Krasimira Aleksandrova Sonja I. Berndt D. Timothy Bishop Hermann Brenner Daniel D. Buchanan Bas Bueno-de-Mesquita Peter T. Campbell Sergi Castellví-Bel Andrew T. Chan Jenny Chang-Claude Merete Ellingjord-Dale Jane C. Figueiredo Steven J. Gallinger Graham G. Giles Edward Giovannucci Stephen B. Gruber Andrea Gsur Jochen Hampe Heather Hampel Sophia Harlid Tabitha A. Harrison Michael Hoffmeister John L. Hopper Li Hsu José María Huerta Jeroen R. Huyghe Mark A. Jenkins Temitope O. Keku Tilman Kühn Carlo La Vecchia Loic Le Marchand Christopher I. Li Li Li Annika Lindblom Noralane M. Lindor Brigid Lynch Sanford D. Markowitz Giovanna Masala Anne M. May Roger Milne Evelyn Monninkhof Lorena Moreno Victor Moreno Polly A. Newcomb Kenneth Offit Vittorio Perduca Paul D. P. Pharoah Elizabeth A. Platz John D. Potter Gad Rennert Elio Riboli Maria-Jose Sánchez Stephanie L. Schmit Robert E. Schoen Gianluca Severi Sabina Sieri Martha L. Slattery Mingyang Song Catherine M. Tangen Stephen N. Thibodeau Ruth C. Travis Antonia Trichopoulou Cornelia M. Ulrich Franzel J. B. van Duijnhoven Bethany Van Guelpen Pavel Vodicka Emily White Alicja Wolk Michael O. Woods Anna H. Wu Ulrike Peters Marc J. Gunter Neil Murphy |
| spellingShingle |
Nikos Papadimitriou Niki Dimou Konstantinos K. Tsilidis Barbara Banbury Richard M. Martin Sarah J. Lewis Nabila Kazmi Timothy M. Robinson Demetrius Albanes Krasimira Aleksandrova Sonja I. Berndt D. Timothy Bishop Hermann Brenner Daniel D. Buchanan Bas Bueno-de-Mesquita Peter T. Campbell Sergi Castellví-Bel Andrew T. Chan Jenny Chang-Claude Merete Ellingjord-Dale Jane C. Figueiredo Steven J. Gallinger Graham G. Giles Edward Giovannucci Stephen B. Gruber Andrea Gsur Jochen Hampe Heather Hampel Sophia Harlid Tabitha A. Harrison Michael Hoffmeister John L. Hopper Li Hsu José María Huerta Jeroen R. Huyghe Mark A. Jenkins Temitope O. Keku Tilman Kühn Carlo La Vecchia Loic Le Marchand Christopher I. Li Li Li Annika Lindblom Noralane M. Lindor Brigid Lynch Sanford D. Markowitz Giovanna Masala Anne M. May Roger Milne Evelyn Monninkhof Lorena Moreno Victor Moreno Polly A. Newcomb Kenneth Offit Vittorio Perduca Paul D. P. Pharoah Elizabeth A. Platz John D. Potter Gad Rennert Elio Riboli Maria-Jose Sánchez Stephanie L. Schmit Robert E. Schoen Gianluca Severi Sabina Sieri Martha L. Slattery Mingyang Song Catherine M. Tangen Stephen N. Thibodeau Ruth C. Travis Antonia Trichopoulou Cornelia M. Ulrich Franzel J. B. van Duijnhoven Bethany Van Guelpen Pavel Vodicka Emily White Alicja Wolk Michael O. Woods Anna H. Wu Ulrike Peters Marc J. Gunter Neil Murphy Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis Nature Communications |
| author_facet |
Nikos Papadimitriou Niki Dimou Konstantinos K. Tsilidis Barbara Banbury Richard M. Martin Sarah J. Lewis Nabila Kazmi Timothy M. Robinson Demetrius Albanes Krasimira Aleksandrova Sonja I. Berndt D. Timothy Bishop Hermann Brenner Daniel D. Buchanan Bas Bueno-de-Mesquita Peter T. Campbell Sergi Castellví-Bel Andrew T. Chan Jenny Chang-Claude Merete Ellingjord-Dale Jane C. Figueiredo Steven J. Gallinger Graham G. Giles Edward Giovannucci Stephen B. Gruber Andrea Gsur Jochen Hampe Heather Hampel Sophia Harlid Tabitha A. Harrison Michael Hoffmeister John L. Hopper Li Hsu José María Huerta Jeroen R. Huyghe Mark A. Jenkins Temitope O. Keku Tilman Kühn Carlo La Vecchia Loic Le Marchand Christopher I. Li Li Li Annika Lindblom Noralane M. Lindor Brigid Lynch Sanford D. Markowitz Giovanna Masala Anne M. May Roger Milne Evelyn Monninkhof Lorena Moreno Victor Moreno Polly A. Newcomb Kenneth Offit Vittorio Perduca Paul D. P. Pharoah Elizabeth A. Platz John D. Potter Gad Rennert Elio Riboli Maria-Jose Sánchez Stephanie L. Schmit Robert E. Schoen Gianluca Severi Sabina Sieri Martha L. Slattery Mingyang Song Catherine M. Tangen Stephen N. Thibodeau Ruth C. Travis Antonia Trichopoulou Cornelia M. Ulrich Franzel J. B. van Duijnhoven Bethany Van Guelpen Pavel Vodicka Emily White Alicja Wolk Michael O. Woods Anna H. Wu Ulrike Peters Marc J. Gunter Neil Murphy |
| author_sort |
Nikos Papadimitriou |
| title |
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis |
| title_short |
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis |
| title_full |
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis |
| title_fullStr |
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis |
| title_full_unstemmed |
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis |
| title_sort |
physical activity and risks of breast and colorectal cancer: a mendelian randomisation analysis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. |
| url |
https://doi.org/10.1038/s41467-020-14389-8 |
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doaj-4037fa7ca3bb4f78b294ecfd1dccdb682021-05-11T09:15:33ZengNature Publishing GroupNature Communications2041-17232020-01-0111111010.1038/s41467-020-14389-8Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysisNikos Papadimitriou0Niki Dimou1Konstantinos K. Tsilidis2Barbara Banbury3Richard M. Martin4Sarah J. Lewis5Nabila Kazmi6Timothy M. Robinson7Demetrius Albanes8Krasimira Aleksandrova9Sonja I. Berndt10D. Timothy Bishop11Hermann Brenner12Daniel D. Buchanan13Bas Bueno-de-Mesquita14Peter T. Campbell15Sergi Castellví-Bel16Andrew T. Chan17Jenny Chang-Claude18Merete Ellingjord-Dale19Jane C. Figueiredo20Steven J. Gallinger21Graham G. Giles22Edward Giovannucci23Stephen B. Gruber24Andrea Gsur25Jochen Hampe26Heather Hampel27Sophia Harlid28Tabitha A. Harrison29Michael Hoffmeister30John L. Hopper31Li Hsu32José María Huerta33Jeroen R. Huyghe34Mark A. Jenkins35Temitope O. Keku36Tilman Kühn37Carlo La Vecchia38Loic Le Marchand39Christopher I. Li40Li Li41Annika Lindblom42Noralane M. Lindor43Brigid Lynch44Sanford D. Markowitz45Giovanna Masala46Anne M. May47Roger Milne48Evelyn Monninkhof49Lorena Moreno50Victor Moreno51Polly A. Newcomb52Kenneth Offit53Vittorio Perduca54Paul D. P. Pharoah55Elizabeth A. Platz56John D. Potter57Gad Rennert58Elio Riboli59Maria-Jose Sánchez60Stephanie L. Schmit61Robert E. Schoen62Gianluca Severi63Sabina Sieri64Martha L. Slattery65Mingyang Song66Catherine M. Tangen67Stephen N. Thibodeau68Ruth C. Travis69Antonia Trichopoulou70Cornelia M. Ulrich71Franzel J. B. van Duijnhoven72Bethany Van Guelpen73Pavel Vodicka74Emily White75Alicja Wolk76Michael O. Woods77Anna H. Wu78Ulrike Peters79Marc J. Gunter80Neil Murphy81Section of Nutrition and Metabolism, International Agency for Research on CancerSection of Nutrition and Metabolism, International Agency for Research on CancerDepartment of Hygiene and Epidemiology, University of Ioannina School of MedicinePublic Health Sciences Division, Fred Hutchinson Cancer Research CenterMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of BristolBristol Medical School, Department of Population Health Sciences, University of BristolMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of BristolBristol Medical School, Department of Population Health Sciences, University of BristolDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthGerman Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthLeeds Institute of Cancer and Pathology, University of LeedsDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneFormer senior scientist, Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1Behavioral and Epidemiology Research Group, American Cancer SocietyGastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of BarcelonaDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical SchoolDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ)Department of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical CenterLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of TorontoCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard UniversityDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern CaliforniaInstitute of Cancer Research, Department of Medicine I, Medical University ViennaDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden)Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer CenterDepartment of Radiation Sciences, Oncology, Umea UniversityPublic Health Sciences Division, Fred Hutchinson Cancer Research CenterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbournePublic Health Sciences Division, Fred Hutchinson Cancer Research CenterCIBER de Epidemiología y Salud Pública (CIBERESP)Public Health Sciences Division, Fred Hutchinson Cancer Research CenterCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneCenter for Gastrointestinal Biology and Disease, University of North CarolinaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ)Hellenic Health FoundationUniversity of Hawaii Cancer CenterPublic Health Sciences Division, Fred Hutchinson Cancer Research CenterDepartment of Family Medicine, University of VirginiaDepartment of Clinical Genetics, Karolinska University HospitalDepartment of Health Science Research, Mayo ClinicCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneDepartments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals of ClevelandCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPROJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of BarcelonaCIBER de Epidemiología y Salud Pública (CIBERESP)Public Health Sciences Division, Fred Hutchinson Cancer Research CenterClinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer CenterCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-SaclayDepartment of Public Health and Primary Care, University of CambridgeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthPublic Health Sciences Division, Fred Hutchinson Cancer Research CenterDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical CenterDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonCIBER de Epidemiología y Salud Pública (CIBERESP)Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern CaliforniaDepartment of Medicine and Epidemiology, University of Pittsburgh Medical CenterCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-SaclayEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei TumoriDepartment of Internal Medicine, University of UtahDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical SchoolSWOG Statistical Center, Fred Hutchinson Cancer Research CenterDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo ClinicCancer Epidemiology Unit, Nuffield Department of Population Health, University of OxfordHellenic Health FoundationHuntsman Cancer Institute and Department of Population Health Sciences, University of UtahDivision of Human Nutrition, Wageningen University and ResearchDepartment of Radiation Sciences, Oncology Unit, Umeå UniversityDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of SciencesPublic Health Sciences Division, Fred Hutchinson Cancer Research CenterInstitute of Environmental Medicine, Karolinska InstitutetMemorial University of Newfoundland, Discipline of GeneticsUniversity of Southern California, Preventative MedicinePublic Health Sciences Division, Fred Hutchinson Cancer Research CenterSection of Nutrition and Metabolism, International Agency for Research on CancerSection of Nutrition and Metabolism, International Agency for Research on CancerPhysical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.https://doi.org/10.1038/s41467-020-14389-8 |