LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames

Blythe et al investigate the patterns of oxidized forms of the 5-methylcytosine DNA modification during spermatogenesis. They find that open reading frames of evolutionarily young and transcriptionally active LINE-1 retrotransposons are enriched in 5-carboxylcytosine (5caC) during spermatid maturati...

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Bibliographic Details
Main Authors: Martin J. Blythe, Ayhan Kocer, Alejandro Rubio-Roldan, Tom Giles, Abdulkadir Abakir, Côme Ialy-Radio, Lee M. Wheldon, Oxana Bereshchenko, Stefano Bruscoli, Alexander Kondrashov, Joël R. Drevet, Richard D. Emes, Andrew D. Johnson, John R. McCarrey, Daniel Gackowski, Ryszard Olinski, Julie Cocquet, Jose L. Garcia-Perez, Alexey Ruzov
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02217-8

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