A modular phosphate tether-mediated divergent strategy to complex polyols

An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple “order of addition” of a pair of olefinic-alcohol components to a pse...

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Main Authors:	Paul R. Hanson, Susanthi Jayasinghe, Soma Maitra, Cornelius N. Ndi, Rambabu Chegondi
Format:	Article
Language:	English
Published:	Beilstein-Institut 2014-10-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	phosphate-tether one-pot sequential processes organophosphorus polyol stereodivergent
Online Access:	https://doi.org/10.3762/bjoc.10.242

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spelling	doaj-40727f912d944f549db0940a9a2cf67e2021-02-02T01:06:59ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-10-011012332233710.3762/bjoc.10.2421860-5397-10-242A modular phosphate tether-mediated divergent strategy to complex polyolsPaul R. Hanson0Susanthi Jayasinghe1Soma Maitra2Cornelius N. Ndi3Rambabu Chegondi4Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USADepartment of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USADepartment of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USADepartment of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USADepartment of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USAAn efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple “order of addition” of a pair of olefinic-alcohol components to a pseudo-C2-symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.https://doi.org/10.3762/bjoc.10.242phosphate-tetherone-potsequential processesorganophosphoruspolyolstereodivergent
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Paul R. Hanson Susanthi Jayasinghe Soma Maitra Cornelius N. Ndi Rambabu Chegondi
spellingShingle	Paul R. Hanson Susanthi Jayasinghe Soma Maitra Cornelius N. Ndi Rambabu Chegondi A modular phosphate tether-mediated divergent strategy to complex polyols Beilstein Journal of Organic Chemistry phosphate-tether one-pot sequential processes organophosphorus polyol stereodivergent
author_facet	Paul R. Hanson Susanthi Jayasinghe Soma Maitra Cornelius N. Ndi Rambabu Chegondi
author_sort	Paul R. Hanson
title	A modular phosphate tether-mediated divergent strategy to complex polyols
title_short	A modular phosphate tether-mediated divergent strategy to complex polyols
title_full	A modular phosphate tether-mediated divergent strategy to complex polyols
title_fullStr	A modular phosphate tether-mediated divergent strategy to complex polyols
title_full_unstemmed	A modular phosphate tether-mediated divergent strategy to complex polyols
title_sort	modular phosphate tether-mediated divergent strategy to complex polyols
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2014-10-01
description	An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple “order of addition” of a pair of olefinic-alcohol components to a pseudo-C2-symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.
topic	phosphate-tether one-pot sequential processes organophosphorus polyol stereodivergent
url	https://doi.org/10.3762/bjoc.10.242
work_keys_str_mv	AT paulrhanson amodularphosphatetethermediateddivergentstrategytocomplexpolyols AT susanthijayasinghe amodularphosphatetethermediateddivergentstrategytocomplexpolyols AT somamaitra amodularphosphatetethermediateddivergentstrategytocomplexpolyols AT corneliusnndi amodularphosphatetethermediateddivergentstrategytocomplexpolyols AT rambabuchegondi amodularphosphatetethermediateddivergentstrategytocomplexpolyols AT paulrhanson modularphosphatetethermediateddivergentstrategytocomplexpolyols AT susanthijayasinghe modularphosphatetethermediateddivergentstrategytocomplexpolyols AT somamaitra modularphosphatetethermediateddivergentstrategytocomplexpolyols AT corneliusnndi modularphosphatetethermediateddivergentstrategytocomplexpolyols AT rambabuchegondi modularphosphatetethermediateddivergentstrategytocomplexpolyols
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A modular phosphate tether-mediated divergent strategy to complex polyols

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