Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis.

Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis.

Inflammation in the early stages of sepsis is governed by the innate immune response. Costimulatory molecules are a receptor/ligand class of molecules capable of regulation of inflammation in innate immunity via macrophage/neutrophil contact. We recently described that CD80/86 ligation is required f...

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Bibliographic Details
Main Authors: Anna Nolan, Hiroshi Kobayashi, Bushra Naveed, Ann Kelly, Yoshihiko Hoshino, Satomi Hoshino, Matthew R Karulf, William N Rom, Michael D Weiden, Jeffrey A Gold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2719911?pdf=render

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