The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons
Obesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area. The human body is mainly composed of two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT); however,...
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doaj-407e8190354b45629885142817e8673f2020-11-25T00:12:31ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-03-011210.3389/fncel.2018.00088300642The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC NeuronsKellen C. da Cruz Rodrigues0Rodrigo M. Pereira1Thaís D. P. de Campos2Rodrigo F. de Moura3Adelino S. R. da Silva4Dennys E. Cintra5Eduardo R. Ropelle6Eduardo R. Ropelle7José R. Pauli8José R. Pauli9Michel B. de Araújo10Leandro P. de Moura11Leandro P. de Moura12Leandro P. de Moura13Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, BrazilLaboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, BrazilLaboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, BrazilDepartment of Health Science, Federal University of Lavras, Lavras, BrazilSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilLaboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, BrazilLaboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, BrazilCenter of Research in Sport Sciences, School of Applied Sciences, University of Campinas, Limeira, BrazilLaboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, BrazilCenter of Research in Sport Sciences, School of Applied Sciences, University of Campinas, Limeira, BrazilUniversity Catholic Center of Quixadá (Unicatolica), Quixadá, BrazilLaboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, BrazilCenter of Research in Sport Sciences, School of Applied Sciences, University of Campinas, Limeira, BrazilPostgraduate Program in Motricity Sciences, São Paulo State University, São Paulo, BrazilObesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area. The human body is mainly composed of two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT); however, the browning process generates a different type of brown fat-like adipocyte in WAT, which similar to BAT has thermogenic capacity by activating UCP-1. The hypothalamic arcuate nucleus plays an important role in WAT browning via POMC neurons, which are influenced by synergistic insulin and leptin signaling. On the other hand, stimulation of AgRP neurons suppresses WAT browning. The hypothalamic inflammatory process that occurs in obesity impairs insulin and leptin signaling in this tissue and, consequently, can decrease WAT browning. In addition, practicing physical exercise may be a great strategy for triggering the browning process since it reduces hypothalamic inflammation and increases POMC neurons gene expression. Moreover, physical exercise stimulates irisin gene expression, which has an important impact on thermogenesis, which in turn culminates in increased gene expression of proteins such as UCP-1 and Cidea, which are related to WAT browning. Furthermore, thermogenetic activation of WAT leads to increased energy expenditure, favoring obesity treatment. Therefore, this mini-review aimed to highlight the most recent studies that link the control of hypothalamic activity with the browning metabolism of adipose tissue in response to physical exercise.http://journal.frontiersin.org/article/10.3389/fncel.2018.00088/fullWAT browningphysical exercisehypothalamusPOMCAgRP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kellen C. da Cruz Rodrigues Rodrigo M. Pereira Thaís D. P. de Campos Rodrigo F. de Moura Adelino S. R. da Silva Dennys E. Cintra Eduardo R. Ropelle Eduardo R. Ropelle José R. Pauli José R. Pauli Michel B. de Araújo Leandro P. de Moura Leandro P. de Moura Leandro P. de Moura |
spellingShingle |
Kellen C. da Cruz Rodrigues Rodrigo M. Pereira Thaís D. P. de Campos Rodrigo F. de Moura Adelino S. R. da Silva Dennys E. Cintra Eduardo R. Ropelle Eduardo R. Ropelle José R. Pauli José R. Pauli Michel B. de Araújo Leandro P. de Moura Leandro P. de Moura Leandro P. de Moura The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons Frontiers in Cellular Neuroscience WAT browning physical exercise hypothalamus POMC AgRP |
author_facet |
Kellen C. da Cruz Rodrigues Rodrigo M. Pereira Thaís D. P. de Campos Rodrigo F. de Moura Adelino S. R. da Silva Dennys E. Cintra Eduardo R. Ropelle Eduardo R. Ropelle José R. Pauli José R. Pauli Michel B. de Araújo Leandro P. de Moura Leandro P. de Moura Leandro P. de Moura |
author_sort |
Kellen C. da Cruz Rodrigues |
title |
The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons |
title_short |
The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons |
title_full |
The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons |
title_fullStr |
The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons |
title_full_unstemmed |
The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons |
title_sort |
role of physical exercise to improve the browning of white adipose tissue via pomc neurons |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2018-03-01 |
description |
Obesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area. The human body is mainly composed of two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT); however, the browning process generates a different type of brown fat-like adipocyte in WAT, which similar to BAT has thermogenic capacity by activating UCP-1. The hypothalamic arcuate nucleus plays an important role in WAT browning via POMC neurons, which are influenced by synergistic insulin and leptin signaling. On the other hand, stimulation of AgRP neurons suppresses WAT browning. The hypothalamic inflammatory process that occurs in obesity impairs insulin and leptin signaling in this tissue and, consequently, can decrease WAT browning. In addition, practicing physical exercise may be a great strategy for triggering the browning process since it reduces hypothalamic inflammation and increases POMC neurons gene expression. Moreover, physical exercise stimulates irisin gene expression, which has an important impact on thermogenesis, which in turn culminates in increased gene expression of proteins such as UCP-1 and Cidea, which are related to WAT browning. Furthermore, thermogenetic activation of WAT leads to increased energy expenditure, favoring obesity treatment. Therefore, this mini-review aimed to highlight the most recent studies that link the control of hypothalamic activity with the browning metabolism of adipose tissue in response to physical exercise. |
topic |
WAT browning physical exercise hypothalamus POMC AgRP |
url |
http://journal.frontiersin.org/article/10.3389/fncel.2018.00088/full |
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