A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial
The aim of the current study was to investigate the effects of a partially hydrolyzed whey infant formula (PHF) on growth in healthy term infants as compared to a standard infant formula with intact protein (IPF). In a double-blind, non-inferiority, randomized controlled trial, a total of 163 health...
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2020-10-01
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doaj-407f91cc80a7491daa8e43a78b0ddb8e2020-11-25T03:28:56ZengMDPI AGNutrients2072-66432020-10-01123056305610.3390/nu12103056A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority TrialEva Karaglani0Inge Thijs-Verhoeven1Marjan Gros2Christina Chairistanidou3Giorgos Zervas4Christina Filoilia5Tarek-Michail Kampani6Vasileios Miligkos7Maria Matiatou8Stavroula Valaveri9Alexandros Sakellariou10Georgios Babilis11Rolf Bos12Yannis Manios13Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave, 17671 Athens, GreeceFrieslandCampina, Stationsplein 1, 3818 LE Amersfoort, The NetherlandsFrieslandCampina, Stationsplein 1, 3818 LE Amersfoort, The NetherlandsDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave, 17671 Athens, GreeceMitera hospital, 6 Erythrou Stavrou Str., 151 23 Athens, GreeceDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave, 17671 Athens, GreeceDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave, 17671 Athens, GreeceMitera hospital, 6 Erythrou Stavrou Str., 151 23 Athens, GreeceMitera hospital, 6 Erythrou Stavrou Str., 151 23 Athens, GreeceMitera hospital, 6 Erythrou Stavrou Str., 151 23 Athens, GreeceDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave, 17671 Athens, GreeceMitera hospital, 6 Erythrou Stavrou Str., 151 23 Athens, GreeceFrieslandCampina, Stationsplein 1, 3818 LE Amersfoort, The NetherlandsDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave, 17671 Athens, GreeceThe aim of the current study was to investigate the effects of a partially hydrolyzed whey infant formula (PHF) on growth in healthy term infants as compared to a standard infant formula with intact protein (IPF). In a double-blind, non-inferiority, randomized controlled trial, a total of 163 healthy formula-fed infants, 55–80 days old, were recruited and randomly allocated to either the PHF (test) or the IPF (control) group. They were followed up for three months during which they were evaluated monthly on growth and development. In total, 21 infants discontinued the study, while 142 infants completed the study (test <i>n </i>= 72, control <i>n </i>= 70). The primary outcome was daily weight gain during the three months. Secondary outcomes included additional anthropometric indices at every timepoint over the intervention period. Daily weight gain during the three-month intervention period was similar in both groups with the lower bound of 95% confidence interval (CI) above the non-inferiority margin of −3 g/day [mean difference (95% CI) test vs. control: −0.474 (−2.460, 1.512) g/day]. Regarding secondary outcomes, i.e., infants’ weight, length, head circumference, body mass index (BMI), and their Z-scores, no differences were observed between the two groups at any time point. The PHF resulted in similar infant growth outcomes as the standard IPF. Based on these results, it can be concluded that the partially hydrolyzed whey infant formula supports adequate growth in healthy term infants.https://www.mdpi.com/2072-6643/12/10/3056infant formulaprotein hydrolysategrowthpartially hydrolyzed formulaanthropometry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eva Karaglani Inge Thijs-Verhoeven Marjan Gros Christina Chairistanidou Giorgos Zervas Christina Filoilia Tarek-Michail Kampani Vasileios Miligkos Maria Matiatou Stavroula Valaveri Alexandros Sakellariou Georgios Babilis Rolf Bos Yannis Manios |
spellingShingle |
Eva Karaglani Inge Thijs-Verhoeven Marjan Gros Christina Chairistanidou Giorgos Zervas Christina Filoilia Tarek-Michail Kampani Vasileios Miligkos Maria Matiatou Stavroula Valaveri Alexandros Sakellariou Georgios Babilis Rolf Bos Yannis Manios A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial Nutrients infant formula protein hydrolysate growth partially hydrolyzed formula anthropometry |
author_facet |
Eva Karaglani Inge Thijs-Verhoeven Marjan Gros Christina Chairistanidou Giorgos Zervas Christina Filoilia Tarek-Michail Kampani Vasileios Miligkos Maria Matiatou Stavroula Valaveri Alexandros Sakellariou Georgios Babilis Rolf Bos Yannis Manios |
author_sort |
Eva Karaglani |
title |
A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial |
title_short |
A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial |
title_full |
A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial |
title_fullStr |
A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial |
title_full_unstemmed |
A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial |
title_sort |
partially hydrolyzed whey infant formula supports appropriate growth: a randomized controlled non-inferiority trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-10-01 |
description |
The aim of the current study was to investigate the effects of a partially hydrolyzed whey infant formula (PHF) on growth in healthy term infants as compared to a standard infant formula with intact protein (IPF). In a double-blind, non-inferiority, randomized controlled trial, a total of 163 healthy formula-fed infants, 55–80 days old, were recruited and randomly allocated to either the PHF (test) or the IPF (control) group. They were followed up for three months during which they were evaluated monthly on growth and development. In total, 21 infants discontinued the study, while 142 infants completed the study (test <i>n </i>= 72, control <i>n </i>= 70). The primary outcome was daily weight gain during the three months. Secondary outcomes included additional anthropometric indices at every timepoint over the intervention period. Daily weight gain during the three-month intervention period was similar in both groups with the lower bound of 95% confidence interval (CI) above the non-inferiority margin of −3 g/day [mean difference (95% CI) test vs. control: −0.474 (−2.460, 1.512) g/day]. Regarding secondary outcomes, i.e., infants’ weight, length, head circumference, body mass index (BMI), and their Z-scores, no differences were observed between the two groups at any time point. The PHF resulted in similar infant growth outcomes as the standard IPF. Based on these results, it can be concluded that the partially hydrolyzed whey infant formula supports adequate growth in healthy term infants. |
topic |
infant formula protein hydrolysate growth partially hydrolyzed formula anthropometry |
url |
https://www.mdpi.com/2072-6643/12/10/3056 |
work_keys_str_mv |
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