Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis
Premedication is important in pediatric anesthesia. This meta-analysis aimed to investigate the role of dexmedetomidine as a premedicant for pediatric patients. A systematic literature search was conducted to identify randomized controlled trials comparing dexmedetomidine premedication with midazola...
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Faculdade de Medicina / USP
2014-11-01
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doaj-408a388a541c49f5996e473df6fccb562020-11-24T23:08:40ZengFaculdade de Medicina / USPClinics1980-53222014-11-01691177778610.6061/clinics/2014(11)12S1807-59322014001100777Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysisKe PengShao-ru WuFu-hai JiJian LiPremedication is important in pediatric anesthesia. This meta-analysis aimed to investigate the role of dexmedetomidine as a premedicant for pediatric patients. A systematic literature search was conducted to identify randomized controlled trials comparing dexmedetomidine premedication with midazolam or ketamine premedication or placebo in children. Two reviewers independently performed the study selection, quality assessment and data extraction. The original data were pooled for the meta-analysis with Review Manager 5. The main parameters investigated included satisfactory separation from parents, satisfactory mask induction, postoperative rescue analgesia, emergence agitation and postoperative nausea and vomiting. Thirteen randomized controlled trials involving 1190 patients were included. When compared with midazolam, premedication with dexmedetomidine resulted in an increase in satisfactory separation from parents (RD = 0.18, 95% CI: 0.06 to 0.30, p = 0.003) and a decrease in the use of postoperative rescue analgesia (RD = -0.19, 95% CI: -0.29 to -0.09, p = 0.0003). Children treated with dexmedetomidine had a lower heart rate before induction. The incidence of satisfactory mask induction, emergence agitation and PONV did not differ between the groups. Dexmedetomidine was superior in providing satisfactory intravenous cannulation compared to placebo. This meta-analysis suggests that dexmedetomidine is superior to midazolam premedication because it resulted in enhanced preoperative sedation and decreased postoperative pain. Additional studies are needed to evaluate the dosing schemes and long-term outcomes of dexmedetomidine premedication in pediatric anesthesia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014001100777&lng=en&tlng=enDexmedetomidinePremedicationPediatricsChildren |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ke Peng Shao-ru Wu Fu-hai Ji Jian Li |
spellingShingle |
Ke Peng Shao-ru Wu Fu-hai Ji Jian Li Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis Clinics Dexmedetomidine Premedication Pediatrics Children |
author_facet |
Ke Peng Shao-ru Wu Fu-hai Ji Jian Li |
author_sort |
Ke Peng |
title |
Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis |
title_short |
Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis |
title_full |
Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis |
title_fullStr |
Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis |
title_full_unstemmed |
Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis |
title_sort |
premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis |
publisher |
Faculdade de Medicina / USP |
series |
Clinics |
issn |
1980-5322 |
publishDate |
2014-11-01 |
description |
Premedication is important in pediatric anesthesia. This meta-analysis aimed to investigate the role of dexmedetomidine as a premedicant for pediatric patients. A systematic literature search was conducted to identify randomized controlled trials comparing dexmedetomidine premedication with midazolam or ketamine premedication or placebo in children. Two reviewers independently performed the study selection, quality assessment and data extraction. The original data were pooled for the meta-analysis with Review Manager 5. The main parameters investigated included satisfactory separation from parents, satisfactory mask induction, postoperative rescue analgesia, emergence agitation and postoperative nausea and vomiting. Thirteen randomized controlled trials involving 1190 patients were included. When compared with midazolam, premedication with dexmedetomidine resulted in an increase in satisfactory separation from parents (RD = 0.18, 95% CI: 0.06 to 0.30, p = 0.003) and a decrease in the use of postoperative rescue analgesia (RD = -0.19, 95% CI: -0.29 to -0.09, p = 0.0003). Children treated with dexmedetomidine had a lower heart rate before induction. The incidence of satisfactory mask induction, emergence agitation and PONV did not differ between the groups. Dexmedetomidine was superior in providing satisfactory intravenous cannulation compared to placebo. This meta-analysis suggests that dexmedetomidine is superior to midazolam premedication because it resulted in enhanced preoperative sedation and decreased postoperative pain. Additional studies are needed to evaluate the dosing schemes and long-term outcomes of dexmedetomidine premedication in pediatric anesthesia. |
topic |
Dexmedetomidine Premedication Pediatrics Children |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014001100777&lng=en&tlng=en |
work_keys_str_mv |
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