Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016
Background: Childhood cancer is a double-edged sword, considering its high rate of response to treatment despite a high vulnerability to develop future malignancies in survivors. Thus, multidisciplinary preventive, curative, and supportive strategies must be incorporated in childhood cancer care tha...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-01-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01428/full |
id |
doaj-4090225c478f49a08cf08f9a031b29ae |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahsima Shabani Mahsima Shabani Sahar Saeedi Moghaddam Bahar Ataeinia Nazila Rezaei Farnam Mohebi Bahram Mohajer Kimiya Gohari Ali Sheidaei Farhad Pishgar Moein Yoosefi Farzad Kompani Farshad Farzadfar Farshad Farzadfar |
spellingShingle |
Mahsima Shabani Mahsima Shabani Sahar Saeedi Moghaddam Bahar Ataeinia Nazila Rezaei Farnam Mohebi Bahram Mohajer Kimiya Gohari Ali Sheidaei Farhad Pishgar Moein Yoosefi Farzad Kompani Farshad Farzadfar Farshad Farzadfar Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016 Frontiers in Oncology neoplasms child incidence mortality Iran |
author_facet |
Mahsima Shabani Mahsima Shabani Sahar Saeedi Moghaddam Bahar Ataeinia Nazila Rezaei Farnam Mohebi Bahram Mohajer Kimiya Gohari Ali Sheidaei Farhad Pishgar Moein Yoosefi Farzad Kompani Farshad Farzadfar Farshad Farzadfar |
author_sort |
Mahsima Shabani |
title |
Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016 |
title_short |
Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016 |
title_full |
Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016 |
title_fullStr |
Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016 |
title_full_unstemmed |
Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016 |
title_sort |
trends of national and subnational incidence of childhood cancer groups in iran: 1990–2016 |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-01-01 |
description |
Background: Childhood cancer is a double-edged sword, considering its high rate of response to treatment despite a high vulnerability to develop future malignancies in survivors. Thus, multidisciplinary preventive, curative, and supportive strategies must be incorporated in childhood cancer care that require understanding the distribution and trend of cancer in the target population. In this article, we aimed to report the national and subnational trends of childhood cancer incidence in Iran from 1990 to 2016, and mortality/incidence ratio (MIR), which, to our knowledge, have not been reported in previous literature.Method: Data on the incidence and mortality rates were collected from the National and Subnational Burden of Diseases project. We employed a two-stage spatiotemporal model to estimate cancer incidences by sex, age, province, and year based on the primary dataset of national death registration system. National and subnational age and gender-specific trends as well as MIR were calculated.Result: The age-standardized incidence rate had a steady increasing trend for cancers in both female [annual percent change (APC), 1.6%] and male (APC, 2.1%) patients. Not only there was an increasing trend in most provinces but also there was a 40% divergence in age-standardized incidence rate at subnational levels. Leukemia, lymphoma, neoplasms of the central nervous system (CNS), digestive tract, endocrine gland, and urinary tract were the leading causes of cancer comprising more than half of all cancers. There was a remarkable general decrease in MIR by 75% as a proxy of care quality.Conclusion: Regarding the increased trend of childhood cancer incidence, there is an essential need to address the etiologic factors and establish preventive plans for childhood cancers. Despite the favorable outcomes observed in cancer care, commensurate health resource allocation must be applied to diminish the subnational disparities. |
topic |
neoplasms child incidence mortality Iran |
url |
https://www.frontiersin.org/article/10.3389/fonc.2019.01428/full |
work_keys_str_mv |
AT mahsimashabani trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT mahsimashabani trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT saharsaeedimoghaddam trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT baharataeinia trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT nazilarezaei trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT farnammohebi trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT bahrammohajer trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT kimiyagohari trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT alisheidaei trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT farhadpishgar trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT moeinyoosefi trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT farzadkompani trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT farshadfarzadfar trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 AT farshadfarzadfar trendsofnationalandsubnationalincidenceofchildhoodcancergroupsiniran19902016 |
_version_ |
1725050203670577152 |
spelling |
doaj-4090225c478f49a08cf08f9a031b29ae2020-11-25T01:39:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-01-01910.3389/fonc.2019.01428472325Trends of National and Subnational Incidence of Childhood Cancer Groups in Iran: 1990–2016Mahsima Shabani0Mahsima Shabani1Sahar Saeedi Moghaddam2Bahar Ataeinia3Nazila Rezaei4Farnam Mohebi5Bahram Mohajer6Kimiya Gohari7Ali Sheidaei8Farhad Pishgar9Moein Yoosefi10Farzad Kompani11Farshad Farzadfar12Farshad Farzadfar13Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranInternational Hematology/Oncology of Pediatrics Experts, Universal Scientific Education and Research Network, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDivision of Hematology and Oncology, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, IranNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranBackground: Childhood cancer is a double-edged sword, considering its high rate of response to treatment despite a high vulnerability to develop future malignancies in survivors. Thus, multidisciplinary preventive, curative, and supportive strategies must be incorporated in childhood cancer care that require understanding the distribution and trend of cancer in the target population. In this article, we aimed to report the national and subnational trends of childhood cancer incidence in Iran from 1990 to 2016, and mortality/incidence ratio (MIR), which, to our knowledge, have not been reported in previous literature.Method: Data on the incidence and mortality rates were collected from the National and Subnational Burden of Diseases project. We employed a two-stage spatiotemporal model to estimate cancer incidences by sex, age, province, and year based on the primary dataset of national death registration system. National and subnational age and gender-specific trends as well as MIR were calculated.Result: The age-standardized incidence rate had a steady increasing trend for cancers in both female [annual percent change (APC), 1.6%] and male (APC, 2.1%) patients. Not only there was an increasing trend in most provinces but also there was a 40% divergence in age-standardized incidence rate at subnational levels. Leukemia, lymphoma, neoplasms of the central nervous system (CNS), digestive tract, endocrine gland, and urinary tract were the leading causes of cancer comprising more than half of all cancers. There was a remarkable general decrease in MIR by 75% as a proxy of care quality.Conclusion: Regarding the increased trend of childhood cancer incidence, there is an essential need to address the etiologic factors and establish preventive plans for childhood cancers. Despite the favorable outcomes observed in cancer care, commensurate health resource allocation must be applied to diminish the subnational disparities.https://www.frontiersin.org/article/10.3389/fonc.2019.01428/fullneoplasmschildincidencemortalityIran |