Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disea...

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Main Authors: Astrid Weiss, Moritz Christian Neubauer, Dinesh Yerabolu, Baktybek Kojonazarov, Beate Christiane Schlueter, Lavinia Neubert, Danny Jonigk, Nelli Baal, Clemens Ruppert, Peter Dorfmuller, Soni Savai Pullamsetti, Norbert Weissmann, Hossein-Ardeschir Ghofrani, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10135-x
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spelling doaj-4090a81f202846ada6a47e71478ee8362021-05-11T11:30:43ZengNature Publishing GroupNature Communications2041-17232019-05-0110111710.1038/s41467-019-10135-xTargeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertensionAstrid Weiss0Moritz Christian Neubauer1Dinesh Yerabolu2Baktybek Kojonazarov3Beate Christiane Schlueter4Lavinia Neubert5Danny Jonigk6Nelli Baal7Clemens Ruppert8Peter Dorfmuller9Soni Savai Pullamsetti10Norbert Weissmann11Hossein-Ardeschir Ghofrani12Friedrich Grimminger13Werner Seeger14Ralph Theo Schermuly15Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Member of the German Center for Lung Research (DZL)Member of the German Center for Lung Research (DZL)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Member of the German Center for Lung Research (DZL)Universities of Giessen and Marburg Lung Center (UGMLC)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent modelshttps://doi.org/10.1038/s41467-019-10135-x
collection DOAJ
language English
format Article
sources DOAJ
author Astrid Weiss
Moritz Christian Neubauer
Dinesh Yerabolu
Baktybek Kojonazarov
Beate Christiane Schlueter
Lavinia Neubert
Danny Jonigk
Nelli Baal
Clemens Ruppert
Peter Dorfmuller
Soni Savai Pullamsetti
Norbert Weissmann
Hossein-Ardeschir Ghofrani
Friedrich Grimminger
Werner Seeger
Ralph Theo Schermuly
spellingShingle Astrid Weiss
Moritz Christian Neubauer
Dinesh Yerabolu
Baktybek Kojonazarov
Beate Christiane Schlueter
Lavinia Neubert
Danny Jonigk
Nelli Baal
Clemens Ruppert
Peter Dorfmuller
Soni Savai Pullamsetti
Norbert Weissmann
Hossein-Ardeschir Ghofrani
Friedrich Grimminger
Werner Seeger
Ralph Theo Schermuly
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
Nature Communications
author_facet Astrid Weiss
Moritz Christian Neubauer
Dinesh Yerabolu
Baktybek Kojonazarov
Beate Christiane Schlueter
Lavinia Neubert
Danny Jonigk
Nelli Baal
Clemens Ruppert
Peter Dorfmuller
Soni Savai Pullamsetti
Norbert Weissmann
Hossein-Ardeschir Ghofrani
Friedrich Grimminger
Werner Seeger
Ralph Theo Schermuly
author_sort Astrid Weiss
title Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_short Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_full Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_fullStr Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_full_unstemmed Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
title_sort targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-05-01
description Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent models
url https://doi.org/10.1038/s41467-019-10135-x
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