Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell Model.

Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell Model.

An initial step in amyloid-β (Aβ) production includes amyloid precursor protein (APP) cleavage via β-Site amyloid precursor protein cleaving enzyme 1 (BACE1). Increased levels of brain Aβ have been implicated in the pathogenesis of Alzheimer's disease (AD). Thus, β-secretase represents a primar...

Full description

Bibliographic Details
Main Authors: Huiyu Liang, Yusheng Shi, Zhewen Kou, Yonghua Peng, Wenjun Chen, Xiaowen Li, Shuji Li, Ying Wang, Fang Wang, Xingmei Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4608735?pdf=render

Similar Items

Similar Items