Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review
Objective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms w...
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Mashhad University of Medical Sciences
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doaj-40982270438647598848219e25fa8a052020-11-24T22:40:41ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742017-12-0120121287129610.22038/ijbms.2017.96209620Mechanisms of spinal cord injury regeneration in zebrafish: a systematic reviewZeynab Noorimotlagh0Mahla Babaie1Mahdi Safdarian2Tahereh Ghadiri3Vafa Rahimi-Movaghar4Medical Student, Iran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, IranMedical Student, Iran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, IranIran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, IranTabriz University of Medical Sciences, Tabriz, IranSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, 11365-3876, IranObjective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L1.1, L1.2, Major vault protein (MVP), contactin-2 and High mobility group box1 (HMGB1) had positive promoting effects on axonal re-growth while Ptena had an inhibitory effect. Neurogenesis is stimulated by Wnt/ß-catenin signaling as well as HMGB1, but inhibited by Notch signaling. Glial cells proliferate in response to fibroblast growth factor (fgf) signaling and Lysophosphatidic acid (LPA). Furthermore, fgf signaling pathway causes glia bridge formation in favor of axonal regeneration. LPA and HMGB1 in acute phase stimulate inflammatory responses around injury and suppress regeneration. LPA also induces microglia activation and neuronal death in addition to glia cell proliferation, but prevents neurite sprouting. Conclusion: This study provides a comprehensive review of the known molecules and mechanisms in the current literature involved in the spinal cord injury (SCI) regeneration in zebrafish, in a time course manner. A better understanding of the whole determining mechanisms for the SCI regeneration should be considered as a main goal for future studies.http://ijbms.mums.ac.ir/article_9620_f5f225b84a2707f8e3368b7d23e4085b.pdfRegeneration recovery of functionSpinal cord regenerationSpinal cord injuriesZebrafish |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zeynab Noorimotlagh Mahla Babaie Mahdi Safdarian Tahereh Ghadiri Vafa Rahimi-Movaghar |
spellingShingle |
Zeynab Noorimotlagh Mahla Babaie Mahdi Safdarian Tahereh Ghadiri Vafa Rahimi-Movaghar Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review Iranian Journal of Basic Medical Sciences Regeneration recovery of function Spinal cord regeneration Spinal cord injuries Zebrafish |
author_facet |
Zeynab Noorimotlagh Mahla Babaie Mahdi Safdarian Tahereh Ghadiri Vafa Rahimi-Movaghar |
author_sort |
Zeynab Noorimotlagh |
title |
Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review |
title_short |
Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review |
title_full |
Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review |
title_fullStr |
Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review |
title_full_unstemmed |
Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review |
title_sort |
mechanisms of spinal cord injury regeneration in zebrafish: a systematic review |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Basic Medical Sciences |
issn |
2008-3866 2008-3874 |
publishDate |
2017-12-01 |
description |
Objective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L1.1, L1.2, Major vault protein (MVP), contactin-2 and High mobility group box1 (HMGB1) had positive promoting effects on axonal re-growth while Ptena had an inhibitory effect. Neurogenesis is stimulated by Wnt/ß-catenin signaling as well as HMGB1, but inhibited by Notch signaling. Glial cells proliferate in response to fibroblast growth factor (fgf) signaling and Lysophosphatidic acid (LPA). Furthermore, fgf signaling pathway causes glia bridge formation in favor of axonal regeneration. LPA and HMGB1 in acute phase stimulate inflammatory responses around injury and suppress regeneration. LPA also induces microglia activation and neuronal death in addition to glia cell proliferation, but prevents neurite sprouting. Conclusion: This study provides a comprehensive review of the known molecules and mechanisms in the current literature involved in the spinal cord injury (SCI) regeneration in zebrafish, in a time course manner. A better understanding of the whole determining mechanisms for the SCI regeneration should be considered as a main goal for future studies. |
topic |
Regeneration recovery of function Spinal cord regeneration Spinal cord injuries Zebrafish |
url |
http://ijbms.mums.ac.ir/article_9620_f5f225b84a2707f8e3368b7d23e4085b.pdf |
work_keys_str_mv |
AT zeynabnoorimotlagh mechanismsofspinalcordinjuryregenerationinzebrafishasystematicreview AT mahlababaie mechanismsofspinalcordinjuryregenerationinzebrafishasystematicreview AT mahdisafdarian mechanismsofspinalcordinjuryregenerationinzebrafishasystematicreview AT taherehghadiri mechanismsofspinalcordinjuryregenerationinzebrafishasystematicreview AT vafarahimimovaghar mechanismsofspinalcordinjuryregenerationinzebrafishasystematicreview |
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