Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction
Background. Changes in cardiopulmonary reserve and biomarkers related to wall stress, inflammation, and oxidative stress concomitantly with the evaluation of peripheral arterial blood flow have not been investigated in patients with heart failure with preserved ejection fraction (HFpEF) compared wit...
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2014-01-01
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Series: | International Journal of Vascular Medicine |
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doaj-40a118ceca0645c7b4d65283291ca1d62021-07-02T02:34:53ZengHindawi LimitedInternational Journal of Vascular Medicine2090-28242090-28322014-01-01201410.1155/2014/917271917271Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection FractionDamien Vitiello0François Harel1Rhian M. Touyz2Martin G. Sirois3Joel Lavoie4Jonathan Myers5Anique Ducharme6Normand Racine7Eileen O’Meara8Mathieu Gayda9Malorie Chabot-Blanchet10Jean Lucien Rouleau11Simon de Denus12Michel White13Research Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UKResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaPalo Alto VA Health Care System, Stanford University, Palo Alto, CA, USAResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaCoordinating Center, Montreal Heart Institute, Montreal, QC, CanadaResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaResearch Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, H1T 1C8, CanadaBackground. Changes in cardiopulmonary reserve and biomarkers related to wall stress, inflammation, and oxidative stress concomitantly with the evaluation of peripheral arterial blood flow have not been investigated in patients with heart failure with preserved ejection fraction (HFpEF) compared with healthy subjects (CTL). Methods and Results. Eighteen HFpEF patients and 14 CTL were recruited. Plasma levels of inflammatory and oxidative stress biomarkers were measured at rest. Brain natriuretic peptide (BNP) was measured at rest and peak exercise. Cardiopulmonary reserve was assessed using an exercise protocol with gas exchange analyses. Peripheral arterial blood flow was determined by strain gauge plethysmography. Peak VO2 (12.0±0.4 versus 19.1±1.1 mL/min/kg, P<0.001) and oxygen uptake efficiency slope (1.55±0.12 versus 2.06±0.14, P<0.05) were significantly decreased in HFpEF patients compared with CTL. BNP at rest and following stress, C-reactive-protein, interleukin-6, and TBARS were significantly elevated in HFpEF. Both basal and posthyperemic arterial blood flow were not significantly different between the HFpEF patients and CTL. Conclusions. HFpEF exhibits a severe reduction in cardiopulmonary reserve and oxygen uptake efficiency concomitantly with an elevation in a broad spectrum of biomarkers confirming an inflammatory and prooxidative status in patients with HFpEF.http://dx.doi.org/10.1155/2014/917271 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Damien Vitiello François Harel Rhian M. Touyz Martin G. Sirois Joel Lavoie Jonathan Myers Anique Ducharme Normand Racine Eileen O’Meara Mathieu Gayda Malorie Chabot-Blanchet Jean Lucien Rouleau Simon de Denus Michel White |
spellingShingle |
Damien Vitiello François Harel Rhian M. Touyz Martin G. Sirois Joel Lavoie Jonathan Myers Anique Ducharme Normand Racine Eileen O’Meara Mathieu Gayda Malorie Chabot-Blanchet Jean Lucien Rouleau Simon de Denus Michel White Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction International Journal of Vascular Medicine |
author_facet |
Damien Vitiello François Harel Rhian M. Touyz Martin G. Sirois Joel Lavoie Jonathan Myers Anique Ducharme Normand Racine Eileen O’Meara Mathieu Gayda Malorie Chabot-Blanchet Jean Lucien Rouleau Simon de Denus Michel White |
author_sort |
Damien Vitiello |
title |
Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction |
title_short |
Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction |
title_full |
Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction |
title_fullStr |
Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction |
title_full_unstemmed |
Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction |
title_sort |
changes in cardiopulmonary reserve and peripheral arterial function concomitantly with subclinical inflammation and oxidative stress in patients with heart failure with preserved ejection fraction |
publisher |
Hindawi Limited |
series |
International Journal of Vascular Medicine |
issn |
2090-2824 2090-2832 |
publishDate |
2014-01-01 |
description |
Background. Changes in cardiopulmonary reserve and biomarkers related to wall stress, inflammation, and oxidative stress concomitantly with the evaluation of peripheral arterial blood flow have not been investigated in patients with heart failure with preserved ejection fraction (HFpEF) compared with healthy subjects (CTL). Methods and Results. Eighteen HFpEF patients and 14 CTL were recruited. Plasma levels of inflammatory and oxidative stress biomarkers were measured at rest. Brain natriuretic peptide (BNP) was measured at rest and peak exercise. Cardiopulmonary reserve was assessed using an exercise protocol with gas exchange analyses. Peripheral arterial blood flow was determined by strain gauge plethysmography. Peak VO2 (12.0±0.4 versus 19.1±1.1 mL/min/kg, P<0.001) and oxygen uptake efficiency slope (1.55±0.12 versus 2.06±0.14, P<0.05) were significantly decreased in HFpEF patients compared with CTL. BNP at rest and following stress, C-reactive-protein, interleukin-6, and TBARS were significantly elevated in HFpEF. Both basal and posthyperemic arterial blood flow were not significantly different between the HFpEF patients and CTL. Conclusions. HFpEF exhibits a severe reduction in cardiopulmonary reserve and oxygen uptake efficiency concomitantly with an elevation in a broad spectrum of biomarkers confirming an inflammatory and prooxidative status in patients with HFpEF. |
url |
http://dx.doi.org/10.1155/2014/917271 |
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