Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes
Background: Congenital heart defects (CHDs) are present in about 40–60% of newborns with Down syndrome (DS). Patients with DS can also develop acquired cardiac disorders. Mouse models suggest that a critical 3.7 Mb region located on human chromosome 21 (HSA21) could explain the association with CHDs...
Main Authors: | Carmela Rita Balistreri, Claudia Leonarda Ammoscato, Letizia Scola, Tiziana Fragapane, Rosa Maria Giarratana, Domenico Lio, Maria Piccione |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | Genes |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4425/11/12/1428 |
Similar Items
-
Inhibition of VEGFA Increases the Sensitivity of Ovarian Cancer Cells to Chemotherapy by Suppressing VEGFA-Mediated Autophagy
by: Li X, et al.
Published: (2020-08-01) -
Vegfa Impacts Early Myocardium Development in Zebrafish
by: Diqi Zhu, et al.
Published: (2017-02-01) -
Role of Spongiotrophoblast VEGFA during Pregnancy
by: Li, Han
Published: (2012) -
Role of Spongiotrophoblast VEGFA during Pregnancy
by: Li, Han
Published: (2012) -
MACC1 promotes angiogenesis in cholangiocarcinoma by upregulating VEGFA
by: Peng T, et al.
Published: (2019-03-01)