On the Morphology of the Drosophila Heart

• Main Authors: Barbara Rotstein, Achim Paululat
• Format: Article
• Language: English
• Published: MDPI AG 2016-04-01
• Series: Journal of Cardiovascular Development and Disease
• Subjects: Drosophila melanogaster; cardiovascular system; heart; dorsal vessel; circulatory system
• Online Access: http://www.mdpi.com/2308-3425/3/2/15

The circulatory system of Drosophila melanogaster represents an easily amenable genetic model whose analysis at different levels, i.e., from single molecules up to functional anatomy, has provided new insights into general aspects of cardiogenesis, heart physiology and cardiac aging, to name a few examples. In recent years, the Drosophila heart has also attracted the attention of researchers in the field of biomedicine. This development is mainly due to the fact that several genes causing human heart disease are also present in Drosophila, where they play the same or similar roles in heart development, maintenance or physiology as their respective counterparts in humans. This review will attempt to briefly introduce the anatomy of the Drosophila circulatory system and then focus on the different cell types and non-cellular tissue that constitute the heart.