Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients

Abstract In a recent report, Ascuntar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we believe that some methodological issues deserve their conclusions. First, the objective...

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Main Authors: Romain Jouffroy, Benoît Vivien
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Intensive Care
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40560-020-00471-2
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spelling doaj-40b0d857dbe540b591f32236aa10f8962020-11-25T03:39:10ZengBMCJournal of Intensive Care2052-04922020-07-01811210.1186/s40560-020-00471-2Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patientsRomain Jouffroy0Benoît Vivien1SAMU de Paris, Service d’Anesthésie Réanimation, Hôpital Universitaire Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, AP-HP.Centre and Université de ParisSAMU de Paris, Service d’Anesthésie Réanimation, Hôpital Universitaire Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, AP-HP.Centre and Université de ParisAbstract In a recent report, Ascuntar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we believe that some methodological issues deserve their conclusions. First, the objective of the authors of an early antibiotic therapy may be ambitious considering practical daily emergency department limitation. Second, most of patients included in the study appear to suffer from sepsis and not from septic shock, which limits the impact of an early and aggressive management. At last, more than a single intervention such as antibiotic therapy, sepsis treatment is now considered as based on a “bundle of care.”http://link.springer.com/article/10.1186/s40560-020-00471-2Antibiotic therapySepsisEarlyMortalityConfounderMethodological issue
collection DOAJ
language English
format Article
sources DOAJ
author Romain Jouffroy
Benoît Vivien
spellingShingle Romain Jouffroy
Benoît Vivien
Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
Journal of Intensive Care
Antibiotic therapy
Sepsis
Early
Mortality
Confounder
Methodological issue
author_facet Romain Jouffroy
Benoît Vivien
author_sort Romain Jouffroy
title Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
title_short Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
title_full Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
title_fullStr Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
title_full_unstemmed Antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
title_sort antimicrobials administration time in patients with suspected sepsis: faster is better for severe patients
publisher BMC
series Journal of Intensive Care
issn 2052-0492
publishDate 2020-07-01
description Abstract In a recent report, Ascuntar et al. describes the impossibility to demonstrate a significant association between early antibiotic therapy administration and mortality in sepsis patients. Nevertheless, we believe that some methodological issues deserve their conclusions. First, the objective of the authors of an early antibiotic therapy may be ambitious considering practical daily emergency department limitation. Second, most of patients included in the study appear to suffer from sepsis and not from septic shock, which limits the impact of an early and aggressive management. At last, more than a single intervention such as antibiotic therapy, sepsis treatment is now considered as based on a “bundle of care.”
topic Antibiotic therapy
Sepsis
Early
Mortality
Confounder
Methodological issue
url http://link.springer.com/article/10.1186/s40560-020-00471-2
work_keys_str_mv AT romainjouffroy antimicrobialsadministrationtimeinpatientswithsuspectedsepsisfasterisbetterforseverepatients
AT benoitvivien antimicrobialsadministrationtimeinpatientswithsuspectedsepsisfasterisbetterforseverepatients
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