Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission
Abstract Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, particularly Lyme borreliosis and tick-borne...
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doaj-40b3de8ee43b4f70abc40b7440f3aacc2020-11-25T03:12:31ZengBMCParasites & Vectors1756-33052019-05-0112112010.1186/s13071-019-3468-xCounterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmissionRyan O. M. Rego0Jos J. A. Trentelman1Juan Anguita2Ard M. Nijhof3Hein Sprong4Boris Klempa5Ondrej Hajdusek6Julen Tomás-Cortázar7Tal Azagi8Martin Strnad9Sarah Knorr10Radek Sima11Marie Jalovecka12Sabína Fumačová Havlíková13Martina Ličková14Monika Sláviková15Petr Kopacek16Libor Grubhoffer17Joppe W. Hovius18Biology Centre, Institute of Parasitology, Czech Academy of SciencesAmsterdam UMC, Location AMC, Center for Experimental and Molecular MedicineCIC bioGUNEInstitute for Parasitology and Tropical Veterinary Medicine, Freie Universität BerlinCentre for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM)Institute of Virology, Biomedical Research Center of the Slovak Academy of SciencesBiology Centre, Institute of Parasitology, Czech Academy of SciencesCIC bioGUNECentre for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM)Biology Centre, Institute of Parasitology, Czech Academy of SciencesInstitute for Parasitology and Tropical Veterinary Medicine, Freie Universität BerlinBiology Centre, Institute of Parasitology, Czech Academy of SciencesBiology Centre, Institute of Parasitology, Czech Academy of SciencesInstitute of Virology, Biomedical Research Center of the Slovak Academy of SciencesInstitute of Virology, Biomedical Research Center of the Slovak Academy of SciencesInstitute of Virology, Biomedical Research Center of the Slovak Academy of SciencesBiology Centre, Institute of Parasitology, Czech Academy of SciencesBiology Centre, Institute of Parasitology, Czech Academy of SciencesAmsterdam UMC, Location AMC, Center for Experimental and Molecular MedicineAbstract Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, particularly Lyme borreliosis and tick-borne encephalitis virus (TBEV). The search for vaccines against these diseases is ongoing. Efforts during the last few decades have primarily focused on understanding the biology of the transmitted viruses, bacteria and protozoans, with the goal of identifying targets for intervention. Successful vaccines have been developed against TBEV and Lyme borreliosis, although the latter is no longer available for humans. More recently, the focus of intervention has shifted back to where it was initially being studied which is the vector. State of the art technologies are being used for the identification of potential vaccine candidates for anti-tick vaccines that could be used either in humans or animals. The study of the interrelationship between ticks and the pathogens they transmit, including mechanisms of acquisition, persistence and transmission have come to the fore, as this knowledge may lead to the identification of critical elements of the pathogens’ life-cycle that could be targeted by vaccines. Here, we review the status of our current knowledge on the triangular relationships between ticks, the pathogens they carry and the mammalian hosts, as well as methods that are being used to identify anti-tick vaccine candidates that can prevent the transmission of tick-borne pathogens.http://link.springer.com/article/10.1186/s13071-019-3468-xTickVaccineIxodesBorreliaTBEVAnaplasma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ryan O. M. Rego Jos J. A. Trentelman Juan Anguita Ard M. Nijhof Hein Sprong Boris Klempa Ondrej Hajdusek Julen Tomás-Cortázar Tal Azagi Martin Strnad Sarah Knorr Radek Sima Marie Jalovecka Sabína Fumačová Havlíková Martina Ličková Monika Sláviková Petr Kopacek Libor Grubhoffer Joppe W. Hovius |
spellingShingle |
Ryan O. M. Rego Jos J. A. Trentelman Juan Anguita Ard M. Nijhof Hein Sprong Boris Klempa Ondrej Hajdusek Julen Tomás-Cortázar Tal Azagi Martin Strnad Sarah Knorr Radek Sima Marie Jalovecka Sabína Fumačová Havlíková Martina Ličková Monika Sláviková Petr Kopacek Libor Grubhoffer Joppe W. Hovius Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission Parasites & Vectors Tick Vaccine Ixodes Borrelia TBEV Anaplasma |
author_facet |
Ryan O. M. Rego Jos J. A. Trentelman Juan Anguita Ard M. Nijhof Hein Sprong Boris Klempa Ondrej Hajdusek Julen Tomás-Cortázar Tal Azagi Martin Strnad Sarah Knorr Radek Sima Marie Jalovecka Sabína Fumačová Havlíková Martina Ličková Monika Sláviková Petr Kopacek Libor Grubhoffer Joppe W. Hovius |
author_sort |
Ryan O. M. Rego |
title |
Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission |
title_short |
Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission |
title_full |
Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission |
title_fullStr |
Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission |
title_full_unstemmed |
Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission |
title_sort |
counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission |
publisher |
BMC |
series |
Parasites & Vectors |
issn |
1756-3305 |
publishDate |
2019-05-01 |
description |
Abstract Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, particularly Lyme borreliosis and tick-borne encephalitis virus (TBEV). The search for vaccines against these diseases is ongoing. Efforts during the last few decades have primarily focused on understanding the biology of the transmitted viruses, bacteria and protozoans, with the goal of identifying targets for intervention. Successful vaccines have been developed against TBEV and Lyme borreliosis, although the latter is no longer available for humans. More recently, the focus of intervention has shifted back to where it was initially being studied which is the vector. State of the art technologies are being used for the identification of potential vaccine candidates for anti-tick vaccines that could be used either in humans or animals. The study of the interrelationship between ticks and the pathogens they transmit, including mechanisms of acquisition, persistence and transmission have come to the fore, as this knowledge may lead to the identification of critical elements of the pathogens’ life-cycle that could be targeted by vaccines. Here, we review the status of our current knowledge on the triangular relationships between ticks, the pathogens they carry and the mammalian hosts, as well as methods that are being used to identify anti-tick vaccine candidates that can prevent the transmission of tick-borne pathogens. |
topic |
Tick Vaccine Ixodes Borrelia TBEV Anaplasma |
url |
http://link.springer.com/article/10.1186/s13071-019-3468-x |
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