Microfluidic Technology for Cell Manipulation
Microfluidic techniques for cell manipulation have been constantly developed and integrated into small chips for high-performance bioassays. However, the drawbacks of each of the techniques often hindered their further advancement and their wide use in biotechnology. To overcome this difficulty, an...
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doaj-40b66c19dbf94ef2b86bccb4143153fd2020-11-24T23:46:04ZengMDPI AGApplied Sciences2076-34172018-06-018699210.3390/app8060992app8060992Microfluidic Technology for Cell ManipulationJae-Sung Kwon0Je Hoon Oh1Department of Mechanical Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, KoreaDepartment of Mechanical Engineering, Hanyang University, 55 Hanyangdaehak-ro, Sangrok-gu, Ansan, Gyeonggi-do 15588, KoreaMicrofluidic techniques for cell manipulation have been constantly developed and integrated into small chips for high-performance bioassays. However, the drawbacks of each of the techniques often hindered their further advancement and their wide use in biotechnology. To overcome this difficulty, an examination and understanding of various aspects of the developed manipulation techniques are required. In this review, we provide the details of primary microfluidic techniques that have received much attention for bioassays. First, we introduce the manipulation techniques using a sole driving source, i.e., dielectrophoresis, electrophoresis, optical tweezers, magnetophoresis, and acoustophoresis. Next, we present rapid electrokinetic patterning, a hybrid opto-electric manipulation technique developed recently. It is introduced in detail along with the underlying physical principle, operating environment, and current challenges. This paper will offer readers the opportunity to improve existing manipulation techniques, suggest new manipulation techniques, and find new applications in biotechnology.http://www.mdpi.com/2076-3417/8/6/992cell manipulationdielectrophoresiselectrophoresisoptical tweezersmagnetophoresisacoustophoresisrapid electrokinetic patterning |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jae-Sung Kwon Je Hoon Oh |
spellingShingle |
Jae-Sung Kwon Je Hoon Oh Microfluidic Technology for Cell Manipulation Applied Sciences cell manipulation dielectrophoresis electrophoresis optical tweezers magnetophoresis acoustophoresis rapid electrokinetic patterning |
author_facet |
Jae-Sung Kwon Je Hoon Oh |
author_sort |
Jae-Sung Kwon |
title |
Microfluidic Technology for Cell Manipulation |
title_short |
Microfluidic Technology for Cell Manipulation |
title_full |
Microfluidic Technology for Cell Manipulation |
title_fullStr |
Microfluidic Technology for Cell Manipulation |
title_full_unstemmed |
Microfluidic Technology for Cell Manipulation |
title_sort |
microfluidic technology for cell manipulation |
publisher |
MDPI AG |
series |
Applied Sciences |
issn |
2076-3417 |
publishDate |
2018-06-01 |
description |
Microfluidic techniques for cell manipulation have been constantly developed and integrated into small chips for high-performance bioassays. However, the drawbacks of each of the techniques often hindered their further advancement and their wide use in biotechnology. To overcome this difficulty, an examination and understanding of various aspects of the developed manipulation techniques are required. In this review, we provide the details of primary microfluidic techniques that have received much attention for bioassays. First, we introduce the manipulation techniques using a sole driving source, i.e., dielectrophoresis, electrophoresis, optical tweezers, magnetophoresis, and acoustophoresis. Next, we present rapid electrokinetic patterning, a hybrid opto-electric manipulation technique developed recently. It is introduced in detail along with the underlying physical principle, operating environment, and current challenges. This paper will offer readers the opportunity to improve existing manipulation techniques, suggest new manipulation techniques, and find new applications in biotechnology. |
topic |
cell manipulation dielectrophoresis electrophoresis optical tweezers magnetophoresis acoustophoresis rapid electrokinetic patterning |
url |
http://www.mdpi.com/2076-3417/8/6/992 |
work_keys_str_mv |
AT jaesungkwon microfluidictechnologyforcellmanipulation AT jehoonoh microfluidictechnologyforcellmanipulation |
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1725494716438413312 |