Verapamil inhibits efflux pumps in Candida albicans, exhibits synergism with fluconazole, and increases survival of Galleria mellonella

Verapamil inhibits efflux pumps in Candida albicans, exhibits synergism with fluconazole, and increases survival of Galleria mellonella

The emergence of resistance requires alternative methods to treat Candida albicans infections. We evaluated efficacy of the efflux pump inhibitor (EPI) verapamil (VER) with fluconazole (FLC) against FLC-resistant (CaR) and -susceptible C. albicans (CaS). The susceptibility of both strains to VER and...

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Bibliographic Details
Main Authors: Yuliana Vega-Chacón, Maria Carolina de Albuquerque, Ana Cláudia Pavarina, Gustavo Henrique Goldman, Ewerton Garcia de Oliveira Mima
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Virulence
Subjects:
candida albicans
membrane transport proteins
virulence
drug resistance
galleria mellonella
Online Access:http://dx.doi.org/10.1080/21505594.2020.1868814

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