Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection
The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell differentiation, cell survival, synaptic plasticity, and both embryonic and adult neurogenesis in central nervous system neur...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/11/5719 |
id |
doaj-40be35b41023480ba67abd76aa251f40 |
---|---|
record_format |
Article |
spelling |
doaj-40be35b41023480ba67abd76aa251f402021-06-01T01:19:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225719571910.3390/ijms22115719Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for NeuroprotectionTadahiro Numakawa0Haruki Odaka1Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, JapanCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, Ibaraki 305-8566, JapanThe function of the brain-derived neurotrophic factor (BDNF) via activation through its high-affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell differentiation, cell survival, synaptic plasticity, and both embryonic and adult neurogenesis in central nervous system neurons. A number of studies have demonstrated the possible involvement of altered expression and action of the BDNF/TrkB signaling in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). In this review, we introduce an essential role of the BDNF and its downstream signaling in neural function. We also review the current evidence on the deregulated the BDNF signaling in the pathophysiology of AD at gene, mRNA, and protein levels. Further, we discuss a potential usefulness of small compounds, including flavonoids, which can stimulate BDNF-related signaling as a BDNF-targeting therapy.https://www.mdpi.com/1422-0067/22/11/5719brain-derived neurotrophic factorAlzheimer’s diseaseintracellular signalingflavonoids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tadahiro Numakawa Haruki Odaka |
spellingShingle |
Tadahiro Numakawa Haruki Odaka Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection International Journal of Molecular Sciences brain-derived neurotrophic factor Alzheimer’s disease intracellular signaling flavonoids |
author_facet |
Tadahiro Numakawa Haruki Odaka |
author_sort |
Tadahiro Numakawa |
title |
Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection |
title_short |
Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection |
title_full |
Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection |
title_fullStr |
Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection |
title_full_unstemmed |
Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection |
title_sort |
brain-derived neurotrophic factor signaling in the pathophysiology of alzheimer’s disease: beneficial effects of flavonoids for neuroprotection |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-05-01 |
description |
The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell differentiation, cell survival, synaptic plasticity, and both embryonic and adult neurogenesis in central nervous system neurons. A number of studies have demonstrated the possible involvement of altered expression and action of the BDNF/TrkB signaling in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). In this review, we introduce an essential role of the BDNF and its downstream signaling in neural function. We also review the current evidence on the deregulated the BDNF signaling in the pathophysiology of AD at gene, mRNA, and protein levels. Further, we discuss a potential usefulness of small compounds, including flavonoids, which can stimulate BDNF-related signaling as a BDNF-targeting therapy. |
topic |
brain-derived neurotrophic factor Alzheimer’s disease intracellular signaling flavonoids |
url |
https://www.mdpi.com/1422-0067/22/11/5719 |
work_keys_str_mv |
AT tadahironumakawa brainderivedneurotrophicfactorsignalinginthepathophysiologyofalzheimersdiseasebeneficialeffectsofflavonoidsforneuroprotection AT harukiodaka brainderivedneurotrophicfactorsignalinginthepathophysiologyofalzheimersdiseasebeneficialeffectsofflavonoidsforneuroprotection |
_version_ |
1721412640161398784 |