Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer
Sirtuins are NAD+-dependent deacylases that play crucial roles in the regulation of cellular metabolism, and as a result, are implicated in several diseases. The mitochondrial sirtuin Sirt4, for a long time considered as mainly a mono-ADP-ribosyltransferase, recently has shown a robust deacylase act...
Main Authors: | Daniela Tomaselli, Clemens Steegborn, Antonello Mai, Dante Rotili |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-04-01
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Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00474/full |
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