Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein

Competition Between Phenothiazines and BH3 Peptide for the Binding Site of the Antiapoptotic BCL-2 Protein

The study of proteins and mechanisms involved in the apoptosis and new knowledge about cancer's biology are essential for planning new drugs. Tumor cells develop several strategies to gain proliferative advantages, including molecular alterations to evade from apoptosis. Failures in apoptosis c...

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Bibliographic Details
Main Authors: Aline Lagoeiro do Carmo, Fernanda Bettanin, Michell Oliveira Almeida, Simone Queiroz Pantaleão, Tiago Rodrigues, Paula Homem-de-Mello, Kathia Maria Honorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Chemistry
Subjects:
apoptosis
cancer
BCL-2
BH3
phenothiazines
docking
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00235/full

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