Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in a wide medical use, yet statins treatment could induce side e...

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Bibliographic Details
Main Authors: Angela Cirigliano, Antonia Amelina, Beatrice Biferali, Alberto Macone, Chiara Mozzetta, Michele Maria Bianchi, Mattia Mori, Bruno Botta, Elah Pick, Rodolfo Negri, Teresa Rinaldi
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
statins
ergosterol
cholesterol
mitochondrial dna
myopathy
Online Access:http://dx.doi.org/10.1080/14756366.2019.1687461

Internet

http://dx.doi.org/10.1080/14756366.2019.1687461

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