Modulating Protein–Protein Interactions by Cyclic and Macrocyclic Peptides. Prominent Strategies and Examples
Cyclic and macrocyclic peptides constitute advanced molecules for modulating protein–protein interactions (PPIs). Although still peptide derivatives, they are metabolically more stable than linear counterparts, and should have a lower degree of flexibility, with more defined secondary structure conf...
Main Authors: | Rosario González-Muñiz, María Ángeles Bonache, María Jesús Pérez de Vega |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/26/2/445 |
Similar Items
-
Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions
by: Naomi S. Robertson, et al.
Published: (2018-04-01) -
Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization
by: Jyotiprasad Mukherjee, et al.
Published: (2015-12-01) -
Biosynthetic Strategies for Macrocyclic Peptides
by: Wei Wang, et al.
Published: (2021-06-01) -
Conformational Studies On Cyclic Pentapeptides And Structural Features In Globular Proteins
by: Nagarajaram, H A
Published: (2012) -
Structurally constrained peptides as protein-protein interaction modulators
by: Ortet, Paula Cristina Teixeira
Published: (2021)