Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid
2,4-Dihydroxybutyric acid has potential to be a precursor to a range of industrially important products, however a natural metabolic pathway for its synthesis does not exist. Here the authors rationally design a synthetic pathway inE. coliby engineering enzymes from malate metabolism.
Bibliographic Details
| Main Authors: |
Thomas Walther,
Christopher M. Topham,
Romain Irague,
Clément Auriol,
Audrey Baylac,
Hélène Cordier,
Clémentine Dressaire,
Luce Lozano-Huguet,
Nathalie Tarrat,
Nelly Martineau,
Marion Stodel,
Yannick Malbert,
Marc Maestracci,
Robert Huet,
Isabelle André,
Magali Remaud-Siméon,
Jean Marie François |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2017-06-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/ncomms15828
|
|---|
