Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale

Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale

Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of system...

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Bibliographic Details
Main Authors: Djuro Kosanovic, Andrey I. Yaroshetskiy, Natalia A. Tsareva, Zamira M. Merzhoeva, Natalia V. Trushenko, Galina V. Nekludova, Ralph Theo Schermuly, Sergey N. Avdeev
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:International Journal of Infectious Diseases
Subjects:
COVID-19
SARS-CoV-2
Acute cor pulmonale
ARDS
Recombinant tissue plasminogen activator
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971220325686
Description
Summary:Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19. We demonstrated that systemic thrombolysis successfully improved the hemodynamics of our patient and resulted in a prominent reduction in hypercapnia, alveolar dead space, and ventilatory ratio.
ISSN:1201-9712

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