Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale

Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of system...

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Main Authors:	Djuro Kosanovic, Andrey I. Yaroshetskiy, Natalia A. Tsareva, Zamira M. Merzhoeva, Natalia V. Trushenko, Galina V. Nekludova, Ralph Theo Schermuly, Sergey N. Avdeev
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Series:	International Journal of Infectious Diseases
Subjects:	COVID-19 SARS-CoV-2 Acute cor pulmonale ARDS Recombinant tissue plasminogen activator
Online Access:	http://www.sciencedirect.com/science/article/pii/S1201971220325686

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spelling	doaj-4104ae19e5754237a93fcd46e29557102021-03-27T04:25:28ZengElsevierInternational Journal of Infectious Diseases1201-97122021-03-01104108110Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonaleDjuro Kosanovic0Andrey I. Yaroshetskiy1Natalia A. Tsareva2Zamira M. Merzhoeva3Natalia V. Trushenko4Galina V. Nekludova5Ralph Theo Schermuly6Sergey N. Avdeev7I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaUniversities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, GermanyI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; Corresponding author at: Department of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia, Trubetskaya Street 8, 119991 Moscow, Russia.Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19. We demonstrated that systemic thrombolysis successfully improved the hemodynamics of our patient and resulted in a prominent reduction in hypercapnia, alveolar dead space, and ventilatory ratio.http://www.sciencedirect.com/science/article/pii/S1201971220325686COVID-19SARS-CoV-2Acute cor pulmonaleARDSRecombinant tissue plasminogen activator
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Djuro Kosanovic Andrey I. Yaroshetskiy Natalia A. Tsareva Zamira M. Merzhoeva Natalia V. Trushenko Galina V. Nekludova Ralph Theo Schermuly Sergey N. Avdeev
spellingShingle	Djuro Kosanovic Andrey I. Yaroshetskiy Natalia A. Tsareva Zamira M. Merzhoeva Natalia V. Trushenko Galina V. Nekludova Ralph Theo Schermuly Sergey N. Avdeev Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale International Journal of Infectious Diseases COVID-19 SARS-CoV-2 Acute cor pulmonale ARDS Recombinant tissue plasminogen activator
author_facet	Djuro Kosanovic Andrey I. Yaroshetskiy Natalia A. Tsareva Zamira M. Merzhoeva Natalia V. Trushenko Galina V. Nekludova Ralph Theo Schermuly Sergey N. Avdeev
author_sort	Djuro Kosanovic
title	Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_short	Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_full	Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_fullStr	Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_full_unstemmed	Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale
title_sort	recombinant tissue plasminogen activator treatment for covid-19 associated ards and acute cor pulmonale
publisher	Elsevier
series	International Journal of Infectious Diseases
issn	1201-9712
publishDate	2021-03-01
description	Existing literature highlights the fact that patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. In this report, we describe the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19. We demonstrated that systemic thrombolysis successfully improved the hemodynamics of our patient and resulted in a prominent reduction in hypercapnia, alveolar dead space, and ventilatory ratio.
topic	COVID-19 SARS-CoV-2 Acute cor pulmonale ARDS Recombinant tissue plasminogen activator
url	http://www.sciencedirect.com/science/article/pii/S1201971220325686
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Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale

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