Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016
Abstract Aims This study aimed to investigate the influence of climatic factors on the onset of Takotsubo syndrome (TTS). Methods and results We performed a retrospective nationwide study among patients registered in the Japanese Registry of All Cardiac and Vascular Diseases and Diagnosis Procedure...
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Online Access: | https://doi.org/10.1002/ehf2.12843 |
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doaj-410823efcf5d42c3b21258c309cffb212021-06-02T08:45:54ZengWileyESC Heart Failure2055-58222020-10-01752629263610.1002/ehf2.12843Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016Koshiro Kanaoka0Satoshi Okayama1Satoshi Terasaki2Tomoya Nakano3Masanobu Ishii4Michikazu Nakai5Kenji Onoue6Kunihiro Nishimura7Satoshi Yasuda8Kenichi Tsujita9Rika Kawakami10Yoshihiro Miyamoto11Hiroyuki Tsutsui12Issei Komuro13Hisao Ogawa14Yoshihiko Saito15Department of Cardiovascular Medicine Nara Medical University 840 Shijo‐cho Kashihara City Nara JapanDepartment of Cardiovascular Medicine Nara Medical University 840 Shijo‐cho Kashihara City Nara JapanDepartment of Cardiovascular Medicine Nara Medical University 840 Shijo‐cho Kashihara City Nara JapanDepartment of Cardiovascular Medicine Nara Medical University 840 Shijo‐cho Kashihara City Nara JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanNational Cerebral and Cardiovascular Center Suita JapanDepartment of Cardiovascular Medicine Nara Medical University 840 Shijo‐cho Kashihara City Nara JapanNational Cerebral and Cardiovascular Center Suita JapanNational Cerebral and Cardiovascular Center Suita JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Cardiovascular Medicine Nara Medical University 840 Shijo‐cho Kashihara City Nara JapanNational Cerebral and Cardiovascular Center Suita JapanDepartment of Cardiovascular Medicine, Faculty of Medical Sciences Kyushu University Fukuoka JapanDepartment of Cardiovascular Medicine The University of Tokyo Graduate School of Medicine Tokyo JapanNational Cerebral and Cardiovascular Center Suita JapanDepartment of Cardiovascular Medicine Nara Medical University 840 Shijo‐cho Kashihara City Nara JapanAbstract Aims This study aimed to investigate the influence of climatic factors on the onset of Takotsubo syndrome (TTS). Methods and results We performed a retrospective nationwide study among patients registered in the Japanese Registry of All Cardiac and Vascular Diseases and Diagnosis Procedure Combination (JROAD–DPC) discharge database, between 2012 and 2016. Before the analysis, a multicentre validation study was conducted for assessing the accuracy of the JROAD–DPC classification for TTS. First, we investigated the seasonal variation of incidences of TTS. Second, we analysed the associations between the incidence of TTS and climatic factors using the hierarchical Poisson regression modelling, and we also investigated the associations between typhoon landfalls and hospitalization for TTS, using the fixed‐effects conditional Poisson regression model. The sensitivity and specificity for diagnosis were 83% and 100%, respectively. Then we analysed 5643 patients with TTS. The mean patient age was 74 (standard deviation ± 11) years; 79% were female. TTS was diagnosed significantly more frequently in the summer and early autumn. The incidence of TTS was related to higher temperatures; adjusted incidence rate ratios were 1.46 [95% confidence interval (CI): 1.33–1.60, P < 0.01] and 1.47 (95% CI: 1.34–1.62, P < 0.01) for temperatures of 20–25°C and >25°C, respectively. The incidence rate ratio for the first 2 days after a typhoon landfall was 1.85 (95% CI: 1.07–3.19; P = 0.03). Conclusions This study demonstrates distinct patterns of seasonal variation in the incidence of TTS, as well as a significant association between its onset and climatic factors, including typhoon landfalls.https://doi.org/10.1002/ehf2.12843Takotsubo syndromeClimatic eventsTyphoonJROAD–DPC |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Koshiro Kanaoka Satoshi Okayama Satoshi Terasaki Tomoya Nakano Masanobu Ishii Michikazu Nakai Kenji Onoue Kunihiro Nishimura Satoshi Yasuda Kenichi Tsujita Rika Kawakami Yoshihiro Miyamoto Hiroyuki Tsutsui Issei Komuro Hisao Ogawa Yoshihiko Saito |
spellingShingle |
Koshiro Kanaoka Satoshi Okayama Satoshi Terasaki Tomoya Nakano Masanobu Ishii Michikazu Nakai Kenji Onoue Kunihiro Nishimura Satoshi Yasuda Kenichi Tsujita Rika Kawakami Yoshihiro Miyamoto Hiroyuki Tsutsui Issei Komuro Hisao Ogawa Yoshihiko Saito Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016 ESC Heart Failure Takotsubo syndrome Climatic events Typhoon JROAD–DPC |
author_facet |
Koshiro Kanaoka Satoshi Okayama Satoshi Terasaki Tomoya Nakano Masanobu Ishii Michikazu Nakai Kenji Onoue Kunihiro Nishimura Satoshi Yasuda Kenichi Tsujita Rika Kawakami Yoshihiro Miyamoto Hiroyuki Tsutsui Issei Komuro Hisao Ogawa Yoshihiko Saito |
author_sort |
Koshiro Kanaoka |
title |
Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016 |
title_short |
Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016 |
title_full |
Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016 |
title_fullStr |
Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016 |
title_full_unstemmed |
Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016 |
title_sort |
role of climatic factors in the incidence of takotsubo syndrome: a nationwide study from 2012 to 2016 |
publisher |
Wiley |
series |
ESC Heart Failure |
issn |
2055-5822 |
publishDate |
2020-10-01 |
description |
Abstract Aims This study aimed to investigate the influence of climatic factors on the onset of Takotsubo syndrome (TTS). Methods and results We performed a retrospective nationwide study among patients registered in the Japanese Registry of All Cardiac and Vascular Diseases and Diagnosis Procedure Combination (JROAD–DPC) discharge database, between 2012 and 2016. Before the analysis, a multicentre validation study was conducted for assessing the accuracy of the JROAD–DPC classification for TTS. First, we investigated the seasonal variation of incidences of TTS. Second, we analysed the associations between the incidence of TTS and climatic factors using the hierarchical Poisson regression modelling, and we also investigated the associations between typhoon landfalls and hospitalization for TTS, using the fixed‐effects conditional Poisson regression model. The sensitivity and specificity for diagnosis were 83% and 100%, respectively. Then we analysed 5643 patients with TTS. The mean patient age was 74 (standard deviation ± 11) years; 79% were female. TTS was diagnosed significantly more frequently in the summer and early autumn. The incidence of TTS was related to higher temperatures; adjusted incidence rate ratios were 1.46 [95% confidence interval (CI): 1.33–1.60, P < 0.01] and 1.47 (95% CI: 1.34–1.62, P < 0.01) for temperatures of 20–25°C and >25°C, respectively. The incidence rate ratio for the first 2 days after a typhoon landfall was 1.85 (95% CI: 1.07–3.19; P = 0.03). Conclusions This study demonstrates distinct patterns of seasonal variation in the incidence of TTS, as well as a significant association between its onset and climatic factors, including typhoon landfalls. |
topic |
Takotsubo syndrome Climatic events Typhoon JROAD–DPC |
url |
https://doi.org/10.1002/ehf2.12843 |
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