Role of MicroRNA in Endometrial Carcinoma
Endometrial carcinoma (EC) is a hall mark of gynecological malignancies that usually affects women above the age 50. It is one of the major causes of mortality in females with ever increasing prevalence and the mortality rate is 1.7 to 2.4 per 100000 and each year 10000 death occur due to ECs. MiRNA...
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doaj-410cfae4b0db4038bcc05174b17059462020-11-24T22:29:17Zeng University of the PunjabAdvancements in Life Sciences2310-53802310-53802016-11-01410813Role of MicroRNA in Endometrial CarcinomaZeeshan Javed0Mukhtar Ullah1Hafiz Ahsan Ashfaq2Afzaal Hussain Shah3Muhammad Shahzad4Muhammad Bilal5Aleena Sumrin6Hamid Bashir7Muhammad Hassan Siddiqi8Haleema Sadia9 Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – Pakistan Centre of Applied Molecular Biology, University of the Punjab, Lahore – PakistanEndometrial carcinoma (EC) is a hall mark of gynecological malignancies that usually affects women above the age 50. It is one of the major causes of mortality in females with ever increasing prevalence and the mortality rate is 1.7 to 2.4 per 100000 and each year 10000 death occur due to ECs. MiRNAs regulate the expression of different proto-oncogenes and signaling pathways that are directly or indirectly involved in the development of cancer. Different miRNAs i.e. (miRNA-449, miRNA 370, miRNA-424, and miRNA-152) which gets up or down regulated during endometrial cancer are the potential biomarkers for early diagnosis of EC. Targeting this relationship between the miRNA and signaling pathways may help in the development of new treatment in endometrial cancer. In current study, we reviewed literature from PubMed using miRNA and endometrial cancer as keywords and outlined the synthesis of potent miRNA and role of different miRNAs involved in ECs. The study revealed different sub types of miRNA played crucial role in the development of cancer by up and down regulation of different metabolic pathways. Many evidences have supported that miRNAs play role in control and regulation of different pathways leading to cancer and targeting these pathways may bring changes in the diagnosis as well as in treatment of EC. http://www.als-journal.com/413-16/miRNA BiogenesisEndometriumCancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zeeshan Javed Mukhtar Ullah Hafiz Ahsan Ashfaq Afzaal Hussain Shah Muhammad Shahzad Muhammad Bilal Aleena Sumrin Hamid Bashir Muhammad Hassan Siddiqi Haleema Sadia |
spellingShingle |
Zeeshan Javed Mukhtar Ullah Hafiz Ahsan Ashfaq Afzaal Hussain Shah Muhammad Shahzad Muhammad Bilal Aleena Sumrin Hamid Bashir Muhammad Hassan Siddiqi Haleema Sadia Role of MicroRNA in Endometrial Carcinoma Advancements in Life Sciences miRNA Biogenesis Endometrium Cancer |
author_facet |
Zeeshan Javed Mukhtar Ullah Hafiz Ahsan Ashfaq Afzaal Hussain Shah Muhammad Shahzad Muhammad Bilal Aleena Sumrin Hamid Bashir Muhammad Hassan Siddiqi Haleema Sadia |
author_sort |
Zeeshan Javed |
title |
Role of MicroRNA in Endometrial Carcinoma |
title_short |
Role of MicroRNA in Endometrial Carcinoma |
title_full |
Role of MicroRNA in Endometrial Carcinoma |
title_fullStr |
Role of MicroRNA in Endometrial Carcinoma |
title_full_unstemmed |
Role of MicroRNA in Endometrial Carcinoma |
title_sort |
role of microrna in endometrial carcinoma |
publisher |
University of the Punjab |
series |
Advancements in Life Sciences |
issn |
2310-5380 2310-5380 |
publishDate |
2016-11-01 |
description |
Endometrial carcinoma (EC) is a hall mark of gynecological malignancies that usually affects women above the age 50. It is one of the major causes of mortality in females with ever increasing prevalence and the mortality rate is 1.7 to 2.4 per 100000 and each year 10000 death occur due to ECs. MiRNAs regulate the expression of different proto-oncogenes and signaling pathways that are directly or indirectly involved in the development of cancer. Different miRNAs i.e. (miRNA-449, miRNA 370, miRNA-424, and miRNA-152) which gets up or down regulated during endometrial cancer are the potential biomarkers for early diagnosis of EC. Targeting this relationship between the miRNA and signaling pathways may help in the development of new treatment in endometrial cancer. In current study, we reviewed literature from PubMed using miRNA and endometrial cancer as keywords and outlined the synthesis of potent miRNA and role of different miRNAs involved in ECs. The study revealed different sub types of miRNA played crucial role in the development of cancer by up and down regulation of different metabolic pathways. Many evidences have supported that miRNAs play role in control and regulation of different pathways leading to cancer and targeting these pathways may bring changes in the diagnosis as well as in treatment of EC. |
topic |
miRNA Biogenesis Endometrium Cancer |
url |
http://www.als-journal.com/413-16/ |
work_keys_str_mv |
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