Calorie restriction with regular chow, but not a high-fat diet, delays onset of spontaneous osteoarthritis in the Hartley guinea pig model

Calorie restriction with regular chow, but not a high-fat diet, delays onset of spontaneous osteoarthritis in the Hartley guinea pig model

Abstract Background Obesity is a leading risk factor for osteoarthritis (OA). In contrast, calorie restriction (CR) may lessen OA due to improved systemic inflammatory status and reduced weight-bearing. The aim of this study was to determine how CR with regular chow versus a high-fat diet (HFD) alte...

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Bibliographic Details
Main Authors: Lauren B. Radakovich, Angela J. Marolf, Lauren A. Culver, Kelly S. Santangelo
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
High-fat diet
Obesity
Calorie restriction
Hartley guinea pig
Online Access:http://link.springer.com/article/10.1186/s13075-019-1925-8

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