LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain

LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain

Epigenetic regulation plays a key role in cortical development. Here the authors show that Rcor2, a co-repressor of the histone demethylase LSD1/KDM1A complex, regulates neural progenitor cell proliferation and cortical neurogenesis by repressing sonic hedgehog signaling.

Bibliographic Details
Main Authors: Yixuan Wang, Qian Wu, Peng Yang, Chenfei Wang, Jing Liu, Wenyu Ding, Wensu Liu, Ye Bai, Yuanyuan Yang, Hong Wang, Shaorong Gao, Xiaoqun Wang
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10481
id doaj-41341f2f73fe4c43bb849a0a45be92ff
record_format Article
spelling doaj-41341f2f73fe4c43bb849a0a45be92ff2021-05-11T11:17:58ZengNature Publishing GroupNature Communications2041-17232016-01-017111410.1038/ncomms10481LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brainYixuan Wang0Qian Wu1Peng Yang2Chenfei Wang3Jing Liu4Wenyu Ding5Wensu Liu6Ye Bai7Yuanyuan Yang8Hong Wang9Shaorong Gao10Xiaoqun Wang11Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji UniversityState Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,National Institute of Biological Sciences (NIBS)Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji UniversityState Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji UniversityClinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji UniversityClinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji UniversityState Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,Epigenetic regulation plays a key role in cortical development. Here the authors show that Rcor2, a co-repressor of the histone demethylase LSD1/KDM1A complex, regulates neural progenitor cell proliferation and cortical neurogenesis by repressing sonic hedgehog signaling.https://doi.org/10.1038/ncomms10481
collection DOAJ
language English
format Article
sources DOAJ
author Yixuan Wang
Qian Wu
Peng Yang
Chenfei Wang
Jing Liu
Wenyu Ding
Wensu Liu
Ye Bai
Yuanyuan Yang
Hong Wang
Shaorong Gao
Xiaoqun Wang
spellingShingle Yixuan Wang
Qian Wu
Peng Yang
Chenfei Wang
Jing Liu
Wenyu Ding
Wensu Liu
Ye Bai
Yuanyuan Yang
Hong Wang
Shaorong Gao
Xiaoqun Wang
LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
Nature Communications
author_facet Yixuan Wang
Qian Wu
Peng Yang
Chenfei Wang
Jing Liu
Wenyu Ding
Wensu Liu
Ye Bai
Yuanyuan Yang
Hong Wang
Shaorong Gao
Xiaoqun Wang
author_sort Yixuan Wang
title LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
title_short LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
title_full LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
title_fullStr LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
title_full_unstemmed LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
title_sort lsd1 co-repressor rcor2 orchestrates neurogenesis in the developing mouse brain
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-01-01
description Epigenetic regulation plays a key role in cortical development. Here the authors show that Rcor2, a co-repressor of the histone demethylase LSD1/KDM1A complex, regulates neural progenitor cell proliferation and cortical neurogenesis by repressing sonic hedgehog signaling.
url https://doi.org/10.1038/ncomms10481
work_keys_str_mv AT yixuanwang lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT qianwu lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT pengyang lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT chenfeiwang lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT jingliu lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT wenyuding lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT wensuliu lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT yebai lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT yuanyuanyang lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT hongwang lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT shaoronggao lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
AT xiaoqunwang lsd1corepressorrcor2orchestratesneurogenesisinthedevelopingmousebrain
_version_ 1721446734677147648

Similar Items