Thickness changes in the corneal epithelium and Bowman’s layer after overnight wear of silicone hydrogel contact lenses
Abstract Background To investigate thickness changes in the corneal epithelium and Bowman’s layer after overnight silicone hydrogel contact lens (CL) wear by using ultra-high resolution optical coherence tomography (UHROCT). Methods Eleven subjects without CL wearing history were recruited for this...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-11-01
|
Series: | BMC Ophthalmology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12886-018-0956-2 |
id |
doaj-41442f0fbcfe477199169f564021d722 |
---|---|
record_format |
Article |
spelling |
doaj-41442f0fbcfe477199169f564021d7222020-11-25T01:33:53ZengBMCBMC Ophthalmology1471-24152018-11-011811710.1186/s12886-018-0956-2Thickness changes in the corneal epithelium and Bowman’s layer after overnight wear of silicone hydrogel contact lensesFan Lu0Aizhu Tao1Weiwei Tao2Xiran Zhuang3Meixiao Shen4School of Ophthalmology and Optometry, Wenzhou Medical UniversitySchool of Ophthalmology and Optometry, Wenzhou Medical UniversityThe First Affiliated Hospital of Wenzhou Medical UniversitySchool of Ophthalmology and Optometry, Wenzhou Medical UniversitySchool of Ophthalmology and Optometry, Wenzhou Medical UniversityAbstract Background To investigate thickness changes in the corneal epithelium and Bowman’s layer after overnight silicone hydrogel contact lens (CL) wear by using ultra-high resolution optical coherence tomography (UHROCT). Methods Eleven subjects without CL wearing history were recruited for this study. An UHROCT was used to measure the thickness of the epithelium (ET), Bowman’s layer (BT), stroma (ST), and total cornea (CCT) at the center of both eyes. A silicone hydrogel CL was inserted in the right eye of each subject, and the fellow non-CL wearing left eye served as the control. The lens was inserted at 9:30 pm and removed at 8:00 am the next morning. The subjects were evaluated at 9:00 pm (baseline), 9:30 pm (lens insertion), 10:00 pm (before sleep), 7:00 am (waking), 7:30 am, and 8:00 am (lens removal). Results Compared to the lens insertion level, the ET of the lens-wearing eye increased by 5.73% at eye opening (P = 0.001). The ET of the non-CL wearing eye and the BT in both eyes did not change after overnight CL wear. Compared to baseline, the CCT of the lens-wearing eye increased by 2.87% upon waking (P = 0.003) and recovered 30 min later (P = 0.555). In contrast, compared to baseline, the CCT of the non-CL wearing eye did not increase upon waking (P = 0.105). Conclusions By using UHROCT, we found that overnight CL wear induced different swelling responses in the various sublayers of the cornea. Trial registration Retrospectively registered. Registration number: ChiCTR1800015115. Registered 07 March 2018.http://link.springer.com/article/10.1186/s12886-018-0956-2ThicknessEpitheliumBowman’s layerOvernightContact lens |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fan Lu Aizhu Tao Weiwei Tao Xiran Zhuang Meixiao Shen |
spellingShingle |
Fan Lu Aizhu Tao Weiwei Tao Xiran Zhuang Meixiao Shen Thickness changes in the corneal epithelium and Bowman’s layer after overnight wear of silicone hydrogel contact lenses BMC Ophthalmology Thickness Epithelium Bowman’s layer Overnight Contact lens |
author_facet |
Fan Lu Aizhu Tao Weiwei Tao Xiran Zhuang Meixiao Shen |
author_sort |
Fan Lu |
title |
Thickness changes in the corneal epithelium and Bowman’s layer after overnight wear of silicone hydrogel contact lenses |
title_short |
Thickness changes in the corneal epithelium and Bowman’s layer after overnight wear of silicone hydrogel contact lenses |
title_full |
Thickness changes in the corneal epithelium and Bowman’s layer after overnight wear of silicone hydrogel contact lenses |
title_fullStr |
Thickness changes in the corneal epithelium and Bowman’s layer after overnight wear of silicone hydrogel contact lenses |
title_full_unstemmed |
Thickness changes in the corneal epithelium and Bowman’s layer after overnight wear of silicone hydrogel contact lenses |
title_sort |
thickness changes in the corneal epithelium and bowman’s layer after overnight wear of silicone hydrogel contact lenses |
publisher |
BMC |
series |
BMC Ophthalmology |
issn |
1471-2415 |
publishDate |
2018-11-01 |
description |
Abstract Background To investigate thickness changes in the corneal epithelium and Bowman’s layer after overnight silicone hydrogel contact lens (CL) wear by using ultra-high resolution optical coherence tomography (UHROCT). Methods Eleven subjects without CL wearing history were recruited for this study. An UHROCT was used to measure the thickness of the epithelium (ET), Bowman’s layer (BT), stroma (ST), and total cornea (CCT) at the center of both eyes. A silicone hydrogel CL was inserted in the right eye of each subject, and the fellow non-CL wearing left eye served as the control. The lens was inserted at 9:30 pm and removed at 8:00 am the next morning. The subjects were evaluated at 9:00 pm (baseline), 9:30 pm (lens insertion), 10:00 pm (before sleep), 7:00 am (waking), 7:30 am, and 8:00 am (lens removal). Results Compared to the lens insertion level, the ET of the lens-wearing eye increased by 5.73% at eye opening (P = 0.001). The ET of the non-CL wearing eye and the BT in both eyes did not change after overnight CL wear. Compared to baseline, the CCT of the lens-wearing eye increased by 2.87% upon waking (P = 0.003) and recovered 30 min later (P = 0.555). In contrast, compared to baseline, the CCT of the non-CL wearing eye did not increase upon waking (P = 0.105). Conclusions By using UHROCT, we found that overnight CL wear induced different swelling responses in the various sublayers of the cornea. Trial registration Retrospectively registered. Registration number: ChiCTR1800015115. Registered 07 March 2018. |
topic |
Thickness Epithelium Bowman’s layer Overnight Contact lens |
url |
http://link.springer.com/article/10.1186/s12886-018-0956-2 |
work_keys_str_mv |
AT fanlu thicknesschangesinthecornealepitheliumandbowmanslayerafterovernightwearofsiliconehydrogelcontactlenses AT aizhutao thicknesschangesinthecornealepitheliumandbowmanslayerafterovernightwearofsiliconehydrogelcontactlenses AT weiweitao thicknesschangesinthecornealepitheliumandbowmanslayerafterovernightwearofsiliconehydrogelcontactlenses AT xiranzhuang thicknesschangesinthecornealepitheliumandbowmanslayerafterovernightwearofsiliconehydrogelcontactlenses AT meixiaoshen thicknesschangesinthecornealepitheliumandbowmanslayerafterovernightwearofsiliconehydrogelcontactlenses |
_version_ |
1725075086547877888 |