Arenaviruses and Lethal Mutagenesis. Prospects for New Ribavirin-based Interventions

Arenaviruses and Lethal Mutagenesis. Prospects for New Ribavirin-based Interventions

Lymphocytic choriomeningitis virus (LCMV) has contributed to unveil some of the molecular mechanisms of lethal mutagenesis, or loss of virus infectivity due to increased mutation rates. Here we review these developments, and provide additional evidence that ribavirin displays a dual mutagenic and in...

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Bibliographic Details
Main Authors: Ana Grande-Pérez, Esteban Domingo, Verónica Martín, Héctor Moreno
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Viruses
Subjects:
viral quasispecies
lymphocytic choriomeningitis virus
5-fluorouracil
antiviral treatment
Online Access:http://www.mdpi.com/1999-4915/4/11/2786

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